The functional role of long noncoding RNA in resistance to anticancer treatment

Yidi Qu, Hor Yue Tan, Yau Tuen Chan, Hongbo Jiang, Ning Wang, Di Wang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

31 Citations (Scopus)

Abstract

Chemotherapy is one of the fundamental methods of cancer treatment. However, drug resistance remains the main cause of clinical treatment failure. We comprehensively review the newly identified roles of long noncoding RNAs (lncRNAs) in oncobiology that are associated with drug resistance. The expression of lncRNAs is tissue-specific and often dysregulated in human cancers. Accumulating evidence suggests that lncRNAs are involved in chemoresistance of cancer cells. The main lncRNA-driven mechanisms of chemoresistance include regulation of drug efflux, DNA damage repair, cell cycle, apoptosis, epithelial-mesenchymal transition (EMT), induction of signaling pathways, and angiogenesis. LncRNA-driven mechanisms of resistance to various antineoplastic agents have been studied extensively. There are unique mechanisms of resistance against different types of drugs, and each mechanism may have more than one contributing factor. We summarize the emerging strategies that can be used to overcome the technical challenges in studying and addressing lncRNA-mediated drug resistance.

Original languageEnglish
Number of pages18
JournalTherapeutic Advances in Medical Oncology
Volume12
DOIs
Publication statusPublished - Jan 2020

Scopus Subject Areas

  • Oncology

User-Defined Keywords

  • cancer
  • drug resistance
  • EMT
  • long noncoding RNAs
  • mechanisms

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