The first conjugate addition reaction of terminal alkynes catalytic in copper: Conjugate addition of alkynes in water

Thomas F. Knöpfel; Erick M. Carreira

doi:10.1021/ja035311z

The first conjugate addition reaction of terminal alkynes catalytic in copper: Conjugate addition of alkynes in water

Thomas F. Knöpfel, Erick M. Carreira^*

^*Corresponding author for this work

Department of Physics

Research output: Contribution to journal › Journal article › peer-review

159 Citations (Scopus)

Abstract

We document that alkynyl copper reagents generated under aqueous conditions from terminal acetylenes, catalytic Cu(OAc)₂, and sodium ascorbate undergo additions to Meldrum's acid-derived Michael acceptors at room temperature (Scheme 1). The additions are not only novel, but also constitute the first example of the conjugate addition reaction of an acetylide catalytic in copper.

Original language	English
Pages (from-to)	6054-6055
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	125
Issue number	20
Early online date	23 Apr 2003
DOIs	https://doi.org/10.1021/ja035311z
Publication status	Published - 21 May 2003

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title = "The first conjugate addition reaction of terminal alkynes catalytic in copper: Conjugate addition of alkynes in water",

abstract = "We document that alkynyl copper reagents generated under aqueous conditions from terminal acetylenes, catalytic Cu(OAc)2, and sodium ascorbate undergo additions to Meldrum's acid-derived Michael acceptors at room temperature (Scheme 1). The additions are not only novel, but also constitute the first example of the conjugate addition reaction of an acetylide catalytic in copper.",

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year = "2003",

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T1 - The first conjugate addition reaction of terminal alkynes catalytic in copper

T2 - Conjugate addition of alkynes in water

AU - Knöpfel, Thomas F.

AU - Carreira, Erick M.

PY - 2003/5/21

Y1 - 2003/5/21

N2 - We document that alkynyl copper reagents generated under aqueous conditions from terminal acetylenes, catalytic Cu(OAc)2, and sodium ascorbate undergo additions to Meldrum's acid-derived Michael acceptors at room temperature (Scheme 1). The additions are not only novel, but also constitute the first example of the conjugate addition reaction of an acetylide catalytic in copper.

AB - We document that alkynyl copper reagents generated under aqueous conditions from terminal acetylenes, catalytic Cu(OAc)2, and sodium ascorbate undergo additions to Meldrum's acid-derived Michael acceptors at room temperature (Scheme 1). The additions are not only novel, but also constitute the first example of the conjugate addition reaction of an acetylide catalytic in copper.

UR - http://www.scopus.com/inward/record.url?scp=0037613482&partnerID=8YFLogxK

U2 - 10.1021/ja035311z

DO - 10.1021/ja035311z

M3 - Journal article

C2 - 12785825

AN - SCOPUS:0037613482

SN - 0002-7863

VL - 125

SP - 6054

EP - 6055

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 20

ER -

The first conjugate addition reaction of terminal alkynes catalytic in copper: Conjugate addition of alkynes in water

Abstract

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