TY - JOUR
T1 - The epigenetic correlation among ovarian cancer, endometriosis and PCOS
T2 - A review
AU - Throwba, Harinee P.K.
AU - Unnikrishnan, Lakshmi
AU - Pangath, Meghna
AU - Vasudevan, Karthick
AU - Jayaraman, Selvaraj
AU - Li, Min
AU - Iyaswamy, Ashok
AU - Palaniyandi, Kanagaraj
AU - Gnanasampanthapandian, Dhanavathy
N1 - Publisher Copyright:
© 2022 The Authors.
PY - 2022/12
Y1 - 2022/12
N2 - Ovarian cancer is a frequent malignancy that affects a large percentage of women. Endometriosis is a chronic condition, where there is a production of benign lesions were observed in the uterine environment. PCOS is a metabolic disorder characterized by the presence of numerous cysts in the ovaries. The relation between ovarian malignancies and PCOS, by an increased ratio of ovarian stromal tissues in PCOS patients. The direct correlation is not yet confirmed among the three disorders, but it is often noted that they share risk factors, such as obesity, hormonal imbalances. Epigenetic factors have shown to be an important reason for cancer progression. Our findings at the epigenetic level includes a comparative analysis, point mutations in genes, overactivation of signaling pathways. This review paper, highlight the possible correlation between the three disorders in terms of genetic and epigenetic factors and how it could together trigger the cancer progression and metastasis.
AB - Ovarian cancer is a frequent malignancy that affects a large percentage of women. Endometriosis is a chronic condition, where there is a production of benign lesions were observed in the uterine environment. PCOS is a metabolic disorder characterized by the presence of numerous cysts in the ovaries. The relation between ovarian malignancies and PCOS, by an increased ratio of ovarian stromal tissues in PCOS patients. The direct correlation is not yet confirmed among the three disorders, but it is often noted that they share risk factors, such as obesity, hormonal imbalances. Epigenetic factors have shown to be an important reason for cancer progression. Our findings at the epigenetic level includes a comparative analysis, point mutations in genes, overactivation of signaling pathways. This review paper, highlight the possible correlation between the three disorders in terms of genetic and epigenetic factors and how it could together trigger the cancer progression and metastasis.
KW - Endometriosis
KW - Epigenetics
KW - Metastasis
KW - Ovarian cancer
KW - PCOS
UR - http://www.scopus.com/inward/record.url?scp=85141456032&partnerID=8YFLogxK
U2 - 10.1016/j.critrevonc.2022.103852
DO - 10.1016/j.critrevonc.2022.103852
M3 - Review article
C2 - 36283585
AN - SCOPUS:85141456032
SN - 1040-8428
VL - 180
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
M1 - 103852
ER -
