The endoplasmic reticulum participated in drug metabolic toxicity

Qingcai Huang, Youwen Chen, Zhengjia Zhang, Zeyu Xue, Zhenglai Hua, Xinyi Luo, Yang Li, Cheng Lu, Aiping Lu, Yuanyan Liu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)


Covalent binding of reactive metabolites formed by drug metabolic activation with biological macromolecules is considered to be an important mechanism of drug metabolic toxicity. Recent studies indicate that the endoplasmic reticulum (ER) could play an important role in drug toxicity by participating in the metabolic activation of drugs and could be a primarily attacked target by reactive metabolites. In this article, we summarize the generation and mechanism of reactive metabolites in ER stress and their associated cell death and inflammatory cascade, as well as the systematic modulation of unfolded protein response (UPR)-mediated adaptive pathways.

Original languageEnglish
Pages (from-to)945-961
Number of pages17
JournalCell Biology and Toxicology
Issue number6
Early online date18 Jan 2022
Publication statusPublished - Dec 2022

Scopus Subject Areas

  • Toxicology
  • Cell Biology
  • Health, Toxicology and Mutagenesis

User-Defined Keywords

  • Apoptosis
  • Drug metabolic toxicity
  • Endoplasmic reticulum
  • Inflammation
  • Reactive metabolites
  • Unfolded protein response


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