The endoplasmic reticulum participated in drug metabolic toxicity

Qingcai Huang; Youwen Chen; Zhengjia Zhang; Zeyu Xue; Zhenglai Hua; Xinyi Luo; Yang Li; Cheng Lu; Aiping Lu; Yuanyan Liu

doi:10.1007/s10565-021-09689-8

The endoplasmic reticulum participated in drug metabolic toxicity

Qingcai Huang, Youwen Chen, Zhengjia Zhang, Zeyu Xue, Zhenglai Hua, Xinyi Luo, Yang Li, Cheng Lu, Aiping Lu, Yuanyan Liu^*

^*Corresponding author for this work

School of Chinese Medicine

Research output: Contribution to journal › Review article › peer-review

6 Citations (Scopus)

Abstract

Covalent binding of reactive metabolites formed by drug metabolic activation with biological macromolecules is considered to be an important mechanism of drug metabolic toxicity. Recent studies indicate that the endoplasmic reticulum (ER) could play an important role in drug toxicity by participating in the metabolic activation of drugs and could be a primarily attacked target by reactive metabolites. In this article, we summarize the generation and mechanism of reactive metabolites in ER stress and their associated cell death and inflammatory cascade, as well as the systematic modulation of unfolded protein response (UPR)-mediated adaptive pathways.

Original language	English
Pages (from-to)	945-961
Number of pages	17
Journal	Cell Biology and Toxicology
Volume	38
Issue number	6
Early online date	18 Jan 2022
DOIs	https://doi.org/10.1007/s10565-021-09689-8
Publication status	Published - Dec 2022

Scopus Subject Areas

Toxicology
Cell Biology
Health, Toxicology and Mutagenesis

User-Defined Keywords

Apoptosis
Drug metabolic toxicity
Endoplasmic reticulum
Inflammation
Reactive metabolites
Unfolded protein response

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10.1007/s10565-021-09689-8

Cite this

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title = "The endoplasmic reticulum participated in drug metabolic toxicity",

abstract = "Covalent binding of reactive metabolites formed by drug metabolic activation with biological macromolecules is considered to be an important mechanism of drug metabolic toxicity. Recent studies indicate that the endoplasmic reticulum (ER) could play an important role in drug toxicity by participating in the metabolic activation of drugs and could be a primarily attacked target by reactive metabolites. In this article, we summarize the generation and mechanism of reactive metabolites in ER stress and their associated cell death and inflammatory cascade, as well as the systematic modulation of unfolded protein response (UPR)-mediated adaptive pathways.",

keywords = "Apoptosis, Drug metabolic toxicity, Endoplasmic reticulum, Inflammation, Reactive metabolites, Unfolded protein response",

author = "Qingcai Huang and Youwen Chen and Zhengjia Zhang and Zeyu Xue and Zhenglai Hua and Xinyi Luo and Yang Li and Cheng Lu and Aiping Lu and Yuanyan Liu",

note = "Funding Information: This work was supported by the Beijing Natural Science Foundation [7202111] and the National Science and Technology Major Project [2018ZX10101001-005-003]. Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Nature B.V.",

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T1 - The endoplasmic reticulum participated in drug metabolic toxicity

AU - Huang, Qingcai

AU - Chen, Youwen

AU - Zhang, Zhengjia

AU - Xue, Zeyu

AU - Hua, Zhenglai

AU - Luo, Xinyi

AU - Li, Yang

AU - Lu, Cheng

AU - Lu, Aiping

AU - Liu, Yuanyan

N1 - Funding Information: This work was supported by the Beijing Natural Science Foundation [7202111] and the National Science and Technology Major Project [2018ZX10101001-005-003]. Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Nature B.V.

PY - 2022/12

Y1 - 2022/12

N2 - Covalent binding of reactive metabolites formed by drug metabolic activation with biological macromolecules is considered to be an important mechanism of drug metabolic toxicity. Recent studies indicate that the endoplasmic reticulum (ER) could play an important role in drug toxicity by participating in the metabolic activation of drugs and could be a primarily attacked target by reactive metabolites. In this article, we summarize the generation and mechanism of reactive metabolites in ER stress and their associated cell death and inflammatory cascade, as well as the systematic modulation of unfolded protein response (UPR)-mediated adaptive pathways.

AB - Covalent binding of reactive metabolites formed by drug metabolic activation with biological macromolecules is considered to be an important mechanism of drug metabolic toxicity. Recent studies indicate that the endoplasmic reticulum (ER) could play an important role in drug toxicity by participating in the metabolic activation of drugs and could be a primarily attacked target by reactive metabolites. In this article, we summarize the generation and mechanism of reactive metabolites in ER stress and their associated cell death and inflammatory cascade, as well as the systematic modulation of unfolded protein response (UPR)-mediated adaptive pathways.

KW - Apoptosis

KW - Drug metabolic toxicity

KW - Endoplasmic reticulum

KW - Inflammation

KW - Reactive metabolites

KW - Unfolded protein response

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U2 - 10.1007/s10565-021-09689-8

DO - 10.1007/s10565-021-09689-8

M3 - Review article

AN - SCOPUS:85123074203

SN - 0742-2091

VL - 38

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EP - 961

JO - Cell Biology and Toxicology

JF - Cell Biology and Toxicology

IS - 6

ER -

The endoplasmic reticulum participated in drug metabolic toxicity

Abstract

Scopus Subject Areas

User-Defined Keywords

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