The endoplasmic reticulum participated in drug metabolic toxicity

Qingcai Huang, Youwen Chen, Zhengjia Zhang, Zeyu Xue, Zhenglai Hua, Xinyi Luo, Yang Li, Cheng Lu, Aiping Lu, Yuanyan Liu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Covalent binding of reactive metabolites formed by drug metabolic activation with biological macromolecules is considered to be an important mechanism of drug metabolic toxicity. Recent studies indicate that the endoplasmic reticulum (ER) could play an important role in drug toxicity by participating in the metabolic activation of drugs and could be a primarily attacked target by reactive metabolites. In this article, we summarize the generation and mechanism of reactive metabolites in ER stress and their associated cell death and inflammatory cascade, as well as the systematic modulation of unfolded protein response (UPR)-mediated adaptive pathways.

Original languageEnglish
JournalCell Biology and Toxicology
DOIs
Publication statusE-pub ahead of print - 18 Jan 2022

Scopus Subject Areas

  • Toxicology
  • Cell Biology
  • Health, Toxicology and Mutagenesis

User-Defined Keywords

  • Apoptosis
  • Drug metabolic toxicity
  • Endoplasmic reticulum
  • Inflammation
  • Reactive metabolites
  • Unfolded protein response

Fingerprint

Dive into the research topics of 'The endoplasmic reticulum participated in drug metabolic toxicity'. Together they form a unique fingerprint.

Cite this