The Effects of Morphology and Linker Length on the Properties of Peptide-Lanthanide Upconversion Nanomaterials as G2 Phase Cell Cycle Inhibitors

Chi Fai Chan, Chen Xie, Ming Kiu Tsang, Sam Lear, Lixiong Dai, Yan Zhou, Jakub Cicho, Miroslaw Karbowiak, Dariusz Hreniak*, Rongfeng Lan, Steve L. Cobb, Michael Hon Wah Lam, Jianhua Hao, Ka-Leung WONG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

In this work, the shape effect of our same-sized hybrid nanomaterials conjugated with two different Plk1-specific peptides had been investigated in terms of their photophysical properties, cellular uptake efficiencies, and selective inhibitory effects towards cancer and normal cells. The results clearly indicate that our spherical NaGdF4@SiO2-P1 nanoparticles achieve the best performance for in vitro imaging, G2 phase cell arrest, and, hence, cell cycle inhibition.

Original languageEnglish
Pages (from-to)4539-4545
Number of pages7
JournalEuropean Journal of Inorganic Chemistry
Volume2015
Issue number27
DOIs
Publication statusPublished - 1 Sep 2015

Scopus Subject Areas

  • Inorganic Chemistry

User-Defined Keywords

  • Antitumor agents
  • Imaging agents
  • Inhibitors
  • Lanthanides
  • Medicinal chemistry
  • Nanoparticles
  • Peptides

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