The effects of methimazole on haematopoiesis in mice

Nai Ki MAK*, W. H. Lai, W. K. Liu, K. N. Leung, M. C. Fung

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

3 Citations (Scopus)


The effects of anti-thyroid drug, methimazole (MMI), on haematopoiesis in inbred C57BL/6 mice were studied. The in vitro proliferative response of bone marrow (BM) cells to interleukin-3 (IL-3) was significantly increased when mice were provided with 0.1% MMI in water (w/v) ad librium for 4 to 6 weeks. Using soft agar agar colony assay, the numbers of myeloid cell colonies were also significantly increased in mice treated with MMI. However, the proliferative response of BM cells to IL-3 was found to be greatly reduced 10 weeks after MMI treatment. In vitro studies showed that MMI alone at the concentrations of 500μM or above inhibited both the growth of normal BM cells in liquid culture and the formation of macrophage (M) - / granulocyte (G) - colonies in soft agar culture in a dose dependent manner. Direct cytotoxic effect of MMI (0 - 1250 μM) to normal BM cells was not observed. Results from this study suggested that MMI can modulate the development of myeloid haematopoietic cells.

Original languageEnglish
Pages (from-to)745-757
Number of pages13
JournalImmunopharmacology and Immunotoxicology
Issue number4
Publication statusPublished - 1995

Scopus Subject Areas

  • Immunology and Allergy
  • Immunology
  • Toxicology
  • Pharmacology


Dive into the research topics of 'The effects of methimazole on haematopoiesis in mice'. Together they form a unique fingerprint.

Cite this