TY - JOUR
T1 - The effect of triptolide in rheumatoid arthritis
T2 - From basic research towards clinical translation
AU - Fan, Danping
AU - Guo, Qingqing
AU - Shen, Jiawen
AU - Zheng, Kang
AU - Lu, Cheng
AU - Zhang, Ge
AU - Lu, Aiping
AU - He, Xiaojuan
N1 - Funding Information:
This study was supported by the Hong Kong Baptist University Strategic Development Fund (SDF15-0324-P02(b)).
PY - 2018/2
Y1 - 2018/2
N2 - Triptolide (TP), a major extract of the herb Tripterygium wilfordii Hook F (TWHF), has been shown to exert potent pharmacological effects, especially an immunosuppressive effect in the treatment of rheumatoid arthritis (RA). However, its multiorgan toxicity prevents it from being widely used in clinical practice. Recently, several attempts are being performed to reduce TP toxicity. In this review, recent progress in the use of TP for RA, including its pharmacological effects and toxicity, is summarized. Meanwhile, strategies relying on chemical structural modifications, innovative delivery systems, and drug combinations to alleviate the disadvantages of TP are also reviewed. Furthermore, we also discuss the challenges and perspectives in their clinical translation.
AB - Triptolide (TP), a major extract of the herb Tripterygium wilfordii Hook F (TWHF), has been shown to exert potent pharmacological effects, especially an immunosuppressive effect in the treatment of rheumatoid arthritis (RA). However, its multiorgan toxicity prevents it from being widely used in clinical practice. Recently, several attempts are being performed to reduce TP toxicity. In this review, recent progress in the use of TP for RA, including its pharmacological effects and toxicity, is summarized. Meanwhile, strategies relying on chemical structural modifications, innovative delivery systems, and drug combinations to alleviate the disadvantages of TP are also reviewed. Furthermore, we also discuss the challenges and perspectives in their clinical translation.
KW - Basic research
KW - Clinical translation
KW - Rheumatoid arthritis
KW - Triptolide
UR - http://www.scopus.com/inward/record.url?scp=85041135170&partnerID=8YFLogxK
U2 - 10.3390/ijms19020376
DO - 10.3390/ijms19020376
M3 - Review article
C2 - 29373547
AN - SCOPUS:85041135170
SN - 1661-6596
VL - 19
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 2
M1 - 376
ER -