The effect of long non-coding RNAs in joint destruction of rheumatoid arthritis

Hanxiao Zhao; Li Li; Ning Zhao; Aiping Lu; Cheng Lu; Xiaojuan He

doi:10.3389/fcell.2022.1011371

The effect of long non-coding RNAs in joint destruction of rheumatoid arthritis

Hanxiao Zhao, Li Li, Ning Zhao, Aiping Lu^*, Cheng Lu^*, Xiaojuan He^*

^*Corresponding author for this work

School of Chinese Medicine

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

Rheumatoid arthritis (RA) is a systemic autoimmune disease accompanied with joint destruction. Serious joint destruction will eventually lead to disability and the decline of life quality in RA patients. At present, the therapeutic effect of drugs to alleviate joint destruction in RA is limited. Recently, accumulating evidences have shown that long non-coding RNAs (lncRNAs) play an important role in the pathogenesis of joint diseases. Therefore, this paper reviews the expression change and the action mechanism of lncRNAs in joint destruction of RA in recent years. A more comprehensive understanding of the role of lncRNAs in joint destruction will help the treatment of RA.

Original language	English
Article number	1011371
Number of pages	10
Journal	Frontiers in Cell and Developmental Biology
Volume	10
DOIs	https://doi.org/10.3389/fcell.2022.1011371
Publication status	Published - 3 Oct 2022

Scopus Subject Areas

Developmental Biology
Cell Biology

User-Defined Keywords

rheumatoid arthritis
lncRNAs
joint destruction
cells
ceRNA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fcell.2022.1011371

Cite this

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title = "The effect of long non-coding RNAs in joint destruction of rheumatoid arthritis",

abstract = "Rheumatoid arthritis (RA) is a systemic autoimmune disease accompanied with joint destruction. Serious joint destruction will eventually lead to disability and the decline of life quality in RA patients. At present, the therapeutic effect of drugs to alleviate joint destruction in RA is limited. Recently, accumulating evidences have shown that long non-coding RNAs (lncRNAs) play an important role in the pathogenesis of joint diseases. Therefore, this paper reviews the expression change and the action mechanism of lncRNAs in joint destruction of RA in recent years. A more comprehensive understanding of the role of lncRNAs in joint destruction will help the treatment of RA.",

keywords = "rheumatoid arthritis, lncRNAs, joint destruction, cells, ceRNA",

author = "Hanxiao Zhao and Li Li and Ning Zhao and Aiping Lu and Cheng Lu and Xiaojuan He",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 Zhao, Li, Zhao, Lu, Lu and He.",

year = "2022",

month = oct,

day = "3",

doi = "10.3389/fcell.2022.1011371",

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journal = "Frontiers in Cell and Developmental Biology",

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TY - JOUR

T1 - The effect of long non-coding RNAs in joint destruction of rheumatoid arthritis

AU - Zhao, Hanxiao

AU - Li, Li

AU - Zhao, Ning

AU - Lu, Aiping

AU - Lu, Cheng

AU - He, Xiaojuan

PY - 2022/10/3

Y1 - 2022/10/3

N2 - Rheumatoid arthritis (RA) is a systemic autoimmune disease accompanied with joint destruction. Serious joint destruction will eventually lead to disability and the decline of life quality in RA patients. At present, the therapeutic effect of drugs to alleviate joint destruction in RA is limited. Recently, accumulating evidences have shown that long non-coding RNAs (lncRNAs) play an important role in the pathogenesis of joint diseases. Therefore, this paper reviews the expression change and the action mechanism of lncRNAs in joint destruction of RA in recent years. A more comprehensive understanding of the role of lncRNAs in joint destruction will help the treatment of RA.

AB - Rheumatoid arthritis (RA) is a systemic autoimmune disease accompanied with joint destruction. Serious joint destruction will eventually lead to disability and the decline of life quality in RA patients. At present, the therapeutic effect of drugs to alleviate joint destruction in RA is limited. Recently, accumulating evidences have shown that long non-coding RNAs (lncRNAs) play an important role in the pathogenesis of joint diseases. Therefore, this paper reviews the expression change and the action mechanism of lncRNAs in joint destruction of RA in recent years. A more comprehensive understanding of the role of lncRNAs in joint destruction will help the treatment of RA.

KW - rheumatoid arthritis

KW - lncRNAs

KW - joint destruction

KW - cells

KW - ceRNA

UR - http://www.scopus.com/inward/record.url?scp=85139912413&partnerID=8YFLogxK

U2 - 10.3389/fcell.2022.1011371

DO - 10.3389/fcell.2022.1011371

M3 - Review article

AN - SCOPUS:85139912413

SN - 2296-634X

VL - 10

JO - Frontiers in Cell and Developmental Biology

JF - Frontiers in Cell and Developmental Biology

M1 - 1011371

ER -

The effect of long non-coding RNAs in joint destruction of rheumatoid arthritis

Abstract

Scopus Subject Areas

User-Defined Keywords

UN SDGs

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