The effect of long non-coding RNAs in joint destruction of rheumatoid arthritis

Hanxiao Zhao, Li Li, Ning Zhao, Aiping Lu*, Cheng Lu*, Xiaojuan He*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Rheumatoid arthritis (RA) is a systemic autoimmune disease accompanied with joint destruction. Serious joint destruction will eventually lead to disability and the decline of life quality in RA patients. At present, the therapeutic effect of drugs to alleviate joint destruction in RA is limited. Recently, accumulating evidences have shown that long non-coding RNAs (lncRNAs) play an important role in the pathogenesis of joint diseases. Therefore, this paper reviews the expression change and the action mechanism of lncRNAs in joint destruction of RA in recent years. A more comprehensive understanding of the role of lncRNAs in joint destruction will help the treatment of RA.

Original languageEnglish
Article number1011371
Number of pages10
JournalFrontiers in Cell and Developmental Biology
Publication statusPublished - 3 Oct 2022

Scopus Subject Areas

  • Developmental Biology
  • Cell Biology

User-Defined Keywords

  • rheumatoid arthritis
  • lncRNAs
  • joint destruction
  • cells
  • ceRNA


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