The effect of interval training on adipokine plasmatic levels in rats with induced myocardial infarction

Mahshid Hosseini, Reza Bagheri, Hussein Nikkar, Julien Baker, Salvador J. Jaime, Zahra Mosayebi, Mohammad Rasoul Zouraghi, Alexei Wong*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

3 Citations (Scopus)


Context: Exercise has been demonstrated to reduce pro-inflammatory while boosting anti-inflammatory adipokines; yet research in relation to Myocardial infarction (MI) is limited. Objective: The aim of this study was to investigate the effect of an interval exercise-training programme on concentrations of Lipocalin-2 and Adiponectin plasmatic levels in rats with induced MI. Materials and methods: The experimental study design comprised of three groups, including: a control group, MI control group and MI training group that participated in an interval training protocol for six weeks. Results: There was a significant increase in Lipocalin-2 levels in the MI interval training group when compared to the other groups. Discussion and conclusion: Although interval training has beneficial effects on adiponectin, it also increases Lipocalin-2 concentrations. Because Lipocalin-2 significantly contributes to the pathogenesis of atherosclerosis and adverse cardiac conditions, our findings suggest that interval training might be a counterproductive strategy to improve MI-related cardiac damage.

Original languageEnglish
Pages (from-to)1249-1253
Number of pages5
JournalArchives of Physiology and Biochemistry
Issue number5
Early online date15 May 2020
Publication statusPublished - 3 Sept 2022

Scopus Subject Areas

  • Physiology
  • Physiology (medical)

User-Defined Keywords

  • Adipokine
  • cardiac rehabilitation
  • interval training
  • myocardial infarction
  • rats


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