The Effect of Abnormal Iron Metabolism on Osteoporosis

Jingmin Che, Jiancheng Yang, Bin Zhao, Ge Zhang, Luyao Wang, Songlin Peng, Peng Shang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

67 Citations (Scopus)


Iron is one of the important trace elements in life activities. Abnormal iron metabolism increases the incidence of many skeletal diseases, especially for osteoporosis. Iron metabolism plays a key role in the bone homeostasis. Disturbance of iron metabolism not only promotes osteoclast differentiation and apoptosis of osteoblasts but also inhibits proliferation and differentiation of osteoblasts, which eventually destroys the balance of bone remodeling. The strength and density of bone can be weakened by the disordered iron metabolism, which increases the incidence of osteoporosis. Clinically, compounds or drugs that regulate iron metabolism are used for the treatment of osteoporosis. The goal of this review summarizes the new progress on the effect of iron overload or deficiency on osteoporosis and the mechanism of disordered iron metabolism on osteoporosis. Explaining the relationship of iron metabolism with osteoporosis may provide ideas for clinical treatment and development of new drugs.

Original languageEnglish
Pages (from-to)353-365
Number of pages13
JournalBiological Trace Element Research
Issue number2
Early online date31 Aug 2019
Publication statusPublished - Jun 2020

Scopus Subject Areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical
  • Inorganic Chemistry

User-Defined Keywords

  • Iron deficiency
  • Iron metabolism
  • Iron overload
  • Osteoporosis


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