The Development of G-Quadruplex-Based Assays for the Detection of Small Molecules and Toxic Substances

Edmond Dik Lung MA*, Chun Wu, Zhen Zhen Dong, Wing Sze Tam, Sze Wan Wong, Chao Yang, Guodong Li, Chung Hang Leung

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)

Abstract

G-Quadruplexes can be induced to form guanine-rich DNA sequences by certain small molecules or metal ions. In concert with an appropriate signal transducer, such as a fluorescent dye or a phosphorescent metal complex, the ligand-recognition event can be transduced into a luminescent response. This focus review aims to highlight recent examples of aptamer-based and metal-mediated G-quadruplex assays for the detection of small molecules and toxic substances in the last three years. We discuss the mechanisms and features of the different assays and present an outlook and a perspective for the future of this field.

Original languageEnglish
Pages (from-to)1851-1860
Number of pages10
JournalChemistry - An Asian Journal
Volume12
Issue number15
DOIs
Publication statusPublished - 4 Aug 2017

Scopus Subject Areas

  • Biochemistry
  • Organic Chemistry

User-Defined Keywords

  • aptamers
  • assays
  • G-quadruplexes
  • luminescence
  • transition metals

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