@article{49db7bd8fdaa4f038d61b6c016e82e2e,
title = "The Development of G-Quadruplex-Based Assays for the Detection of Small Molecules and Toxic Substances",
abstract = "G-Quadruplexes can be induced to form guanine-rich DNA sequences by certain small molecules or metal ions. In concert with an appropriate signal transducer, such as a fluorescent dye or a phosphorescent metal complex, the ligand-recognition event can be transduced into a luminescent response. This focus review aims to highlight recent examples of aptamer-based and metal-mediated G-quadruplex assays for the detection of small molecules and toxic substances in the last three years. We discuss the mechanisms and features of the different assays and present an outlook and a perspective for the future of this field.",
keywords = "aptamers, assays, G-quadruplexes, luminescence, transition metals",
author = "Ma, {Dik Lung} and Chun Wu and Dong, {Zhen Zhen} and Tam, {Wing Sze} and Wong, {Sze Wan} and Chao Yang and Guodong Li and Leung, {Chung Hang}",
note = "Funding Information: Chung-Hang Leung completed his Ph.D. degree in 2002 at the City University of Hong Kong. After completing a five-year postdoctoral fellowship at the Department of Pharmacology, Yale University, he was appointed Research Assistant Professor at the University of Hong Kong and then at Hong Kong Baptist University. He is currently an Associate Professor at the University of Macau. His primary research interests include anticancer and anti-inflammatory drug discovery and molecular biology. Funding Information: This work was supported by the Hong Kong Baptist University (FRG2/15–16/002), the Health and Medical Research Fund (HMRF/14130522), the Research Grants Council (HKBU/ 12301115, HKBU/204612 and HKBU/201913), the National Natural Science Foundation of China (21575121 and 21628502), the Guangdong Province Natural Science Foundation (2015A030313816), the Hong Kong Baptist University Century Club Sponsorship Scheme 2016, the Interdisciplinary Research Matching Scheme (RC-IRMS/15-16/03), the Science and Technology Development Fund, Macao SAR (077/2016/A2 and 007/ 2014/AMJ), and the University of Macau (MYRG2015-00137-ICMS-QRCM, MYRG2016-00151-ICMS-QRCM and MRG044/LCH/ 2015/ICMS).",
year = "2017",
month = aug,
day = "4",
doi = "10.1002/asia.201700533",
language = "English",
volume = "12",
pages = "1851--1860",
journal = "Chemistry - An Asian Journal",
issn = "1861-4728",
publisher = "John Wiley & Sons Ltd.",
number = "15",
}