The development of chitosan based microcapsules as delivery vehicles for orally administered daunorubicin

P. L. Lam; K. K.H. Lee; Y. W. Ho; R. S.M. Wong; S. W. Tong; C. H. Cheng; K. H. Lam; J. C.O. Tang; Zhaoxiang BIAN; R. Gambari; S. H.L. Kok; Chung Hin CHUI

doi:10.1039/c4ra00195h

The development of chitosan based microcapsules as delivery vehicles for orally administered daunorubicin

P. L. Lam
, K. K.H. Lee
, Y. W. Ho
, R. S.M. Wong
, S. W. Tong
, C. H. Cheng
, K. H. Lam
, J. C.O. Tang
, Zhaoxiang BIAN
, R. Gambari^*
, S. H.L. Kok
, Chung Hin CHUI

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

11 Citations (Scopus)

Abstract

This study reports the use of chitosan microcapsules for daunorubicin delivery via an oral route. The potential oral delivery of the daunorubicin/chitosan microcapsules was examined using an in vivo athymic nude mice xenograft model with Non-Hodgkin's lymphoma cells. Microencapsulated daunorubicin could be administered orally with tumour growth inhibition activity.

Original language	English
Pages (from-to)	14109-14114
Number of pages	6
Journal	RSC Advances
Volume	4
Issue number	27
DOIs	https://doi.org/10.1039/c4ra00195h
Publication status	Published - 2014

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c4ra00195h

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title = "The development of chitosan based microcapsules as delivery vehicles for orally administered daunorubicin",

abstract = "This study reports the use of chitosan microcapsules for daunorubicin delivery via an oral route. The potential oral delivery of the daunorubicin/chitosan microcapsules was examined using an in vivo athymic nude mice xenograft model with Non-Hodgkin's lymphoma cells. Microencapsulated daunorubicin could be administered orally with tumour growth inhibition activity.",

author = "Lam, \{P. L.\} and Lee, \{K. K.H.\} and Ho, \{Y. W.\} and Wong, \{R. S.M.\} and Tong, \{S. W.\} and Cheng, \{C. H.\} and Lam, \{K. H.\} and Tang, \{J. C.O.\} and Zhaoxiang BIAN and R. Gambari and Kok, \{S. H.L.\} and CHUI, \{Chung Hin\}",

year = "2014",

doi = "10.1039/c4ra00195h",

language = "English",

volume = "4",

pages = "14109--14114",

journal = "RSC Advances",

issn = "2046-2069",

publisher = "Royal Society of Chemistry",

number = "27",

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TY - JOUR

T1 - The development of chitosan based microcapsules as delivery vehicles for orally administered daunorubicin

AU - Lam, P. L.

AU - Lee, K. K.H.

AU - Ho, Y. W.

AU - Wong, R. S.M.

AU - Tong, S. W.

AU - Cheng, C. H.

AU - Lam, K. H.

AU - Tang, J. C.O.

AU - BIAN, Zhaoxiang

AU - Gambari, R.

AU - Kok, S. H.L.

AU - CHUI, Chung Hin

PY - 2014

Y1 - 2014

N2 - This study reports the use of chitosan microcapsules for daunorubicin delivery via an oral route. The potential oral delivery of the daunorubicin/chitosan microcapsules was examined using an in vivo athymic nude mice xenograft model with Non-Hodgkin's lymphoma cells. Microencapsulated daunorubicin could be administered orally with tumour growth inhibition activity.

AB - This study reports the use of chitosan microcapsules for daunorubicin delivery via an oral route. The potential oral delivery of the daunorubicin/chitosan microcapsules was examined using an in vivo athymic nude mice xenograft model with Non-Hodgkin's lymphoma cells. Microencapsulated daunorubicin could be administered orally with tumour growth inhibition activity.

UR - https://www.scopus.com/pages/publications/84896913672

U2 - 10.1039/c4ra00195h

DO - 10.1039/c4ra00195h

M3 - Journal article

AN - SCOPUS:84896913672

SN - 2046-2069

VL - 4

SP - 14109

EP - 14114

JO - RSC Advances

JF - RSC Advances

IS - 27

ER -

The development of chitosan based microcapsules as delivery vehicles for orally administered daunorubicin

Abstract

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