The critical roles of mitophagy in cerebral ischemia

Yan Cheng Tang; Hong Xia Tian; Tao Yi; Hubiao Chen

doi:10.1007/s13238-016-0307-0

The critical roles of mitophagy in cerebral ischemia

Yan Cheng Tang
, Hong Xia Tian
, Tao Yi^*
, Hubiao Chen

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

115 Citations (Scopus)

37 Downloads (Pure)

Abstract

Mitochondria play a key role in various cell processes including ATP production, Ca² ⁺ homeostasis, reactive oxygen species (ROS) generation, and apoptosis. The selective removal of impaired mitochondria by autophagosome is known as mitophagy. Cerebral ischemia is a common form of stroke caused by insufficient blood supply to the brain. Emerging evidence suggests that mitophagy plays important roles in the pathophysiological process of cerebral ischemia. This review focuses on the relationship between ischemic brain injury and mitophagy. Based on the latest research, it describes how the signaling pathways of mitophagy appear to be involved in cerebral ischemia.

Original language	English
Pages (from-to)	699-713
Number of pages	15
Journal	Protein and Cell
Volume	7
Issue number	10
DOIs	https://doi.org/10.1007/s13238-016-0307-0
Publication status	Published - 1 Oct 2016

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

User-Defined Keywords

autophagy
cerebral ischemia
mitochondria
mitophagy

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10.1007/s13238-016-0307-0

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Cite this

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title = "The critical roles of mitophagy in cerebral ischemia",

abstract = "Mitochondria play a key role in various cell processes including ATP production, Ca2 + homeostasis, reactive oxygen species (ROS) generation, and apoptosis. The selective removal of impaired mitochondria by autophagosome is known as mitophagy. Cerebral ischemia is a common form of stroke caused by insufficient blood supply to the brain. Emerging evidence suggests that mitophagy plays important roles in the pathophysiological process of cerebral ischemia. This review focuses on the relationship between ischemic brain injury and mitophagy. Based on the latest research, it describes how the signaling pathways of mitophagy appear to be involved in cerebral ischemia.",

keywords = "autophagy, cerebral ischemia, mitochondria, mitophagy",

author = "Tang, \{Yan Cheng\} and Tian, \{Hong Xia\} and Tao Yi and Hubiao Chen",

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year = "2016",

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doi = "10.1007/s13238-016-0307-0",

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TY - JOUR

T1 - The critical roles of mitophagy in cerebral ischemia

AU - Tang, Yan Cheng

AU - Tian, Hong Xia

AU - Yi, Tao

AU - Chen, Hubiao

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Mitochondria play a key role in various cell processes including ATP production, Ca2 + homeostasis, reactive oxygen species (ROS) generation, and apoptosis. The selective removal of impaired mitochondria by autophagosome is known as mitophagy. Cerebral ischemia is a common form of stroke caused by insufficient blood supply to the brain. Emerging evidence suggests that mitophagy plays important roles in the pathophysiological process of cerebral ischemia. This review focuses on the relationship between ischemic brain injury and mitophagy. Based on the latest research, it describes how the signaling pathways of mitophagy appear to be involved in cerebral ischemia.

AB - Mitochondria play a key role in various cell processes including ATP production, Ca2 + homeostasis, reactive oxygen species (ROS) generation, and apoptosis. The selective removal of impaired mitochondria by autophagosome is known as mitophagy. Cerebral ischemia is a common form of stroke caused by insufficient blood supply to the brain. Emerging evidence suggests that mitophagy plays important roles in the pathophysiological process of cerebral ischemia. This review focuses on the relationship between ischemic brain injury and mitophagy. Based on the latest research, it describes how the signaling pathways of mitophagy appear to be involved in cerebral ischemia.

KW - autophagy

KW - cerebral ischemia

KW - mitochondria

KW - mitophagy

UR - https://www.scopus.com/pages/publications/84983427033

U2 - 10.1007/s13238-016-0307-0

DO - 10.1007/s13238-016-0307-0

M3 - Review article

C2 - 27554669

AN - SCOPUS:84983427033

SN - 1674-800X

VL - 7

SP - 699

EP - 713

JO - Protein and Cell

JF - Protein and Cell

IS - 10

ER -

The critical roles of mitophagy in cerebral ischemia

Abstract

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