The critical roles of mitophagy in cerebral ischemia

Yan Cheng Tang, Hong Xia Tian, Tao Yi*, Hubiao Chen

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

79 Citations (Scopus)
9 Downloads (Pure)


Mitochondria play a key role in various cell processes including ATP production, Ca2 + homeostasis, reactive oxygen species (ROS) generation, and apoptosis. The selective removal of impaired mitochondria by autophagosome is known as mitophagy. Cerebral ischemia is a common form of stroke caused by insufficient blood supply to the brain. Emerging evidence suggests that mitophagy plays important roles in the pathophysiological process of cerebral ischemia. This review focuses on the relationship between ischemic brain injury and mitophagy. Based on the latest research, it describes how the signaling pathways of mitophagy appear to be involved in cerebral ischemia.

Original languageEnglish
Pages (from-to)699-713
Number of pages15
JournalProtein and Cell
Issue number10
Publication statusPublished - 1 Oct 2016

Scopus Subject Areas

  • Biotechnology
  • Biochemistry
  • Drug Discovery
  • Cell Biology

User-Defined Keywords

  • autophagy
  • cerebral ischemia
  • mitochondria
  • mitophagy


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