The changing HIV-1 genetic characteristics and transmitted drug resistance among recently infected population in Yunnan, China

M. Chen, M. H. Jia, Y. L. Ma, H. B. Luo, H. C. Chen, C. J. Yang, J. Dai, L. Yang, L. J. Dong, R. Lu, L. J. Song, Y. Han, J. Y. Lu, Ka Loon Allen CHEUNG, Z. W. Chen, L. Lu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Multiple human immunodeficiency virus (HIV)-1 genotypes in China were first discovered in Yunnan Province before disseminating throughout the country. As the HIV-1 epidemic continues to expand in Yunnan, genetic characteristics and transmitted drug resistance (TDR) should be further investigated among the recently infected population. Among 2828 HIV-positive samples newly reported in the first quarter of 2014, 347 were identified as recent infections with BED-captured enzyme immunoassay (CEIA). Of them, 291 were successfully genotyped and identified as circulating recombinant form (CRF)08-BC (47.4%), unique recombinant forms (URFs) (18.2%), CRF01-AE (15.8%), CRF07-BC (14.4%), subtype C (2.7%), CRF55-01B (0.7%), subtype B (0.3%) and CRF64-BC (0.3%). CRF08-BC and CRF01-AE were the predominant genotypes among heterosexual and homosexual infections, respectively. CRF08-BC, URFs, CRF01-AE and CRF07-BC expanded with higher prevalence in central and eastern Yunnan. The recent common ancestor of CRF01-AE, CRF07-BC and CRF08-BC dated back to 1983.1, 1992.1 and 1989.5, respectively. The effective population sizes (EPS) for CRF01-AE and CRF07-BC increased exponentially during 1991-1999 and 1994-1999, respectively. The EPS for CRF08-BC underwent two exponential growth phases in 1994-1998 and 2001-2002. Lastly, TDR-associated mutations were identified in 1.8% of individuals. These findings not only enhance our understanding of HIV-1 evolution in Yunnan but also have implications for vaccine design and patient management strategies.

Original languageEnglish
Pages (from-to)775-781
Number of pages7
JournalEpidemiology and Infection
Volume146
Issue number6
DOIs
Publication statusPublished - 1 Apr 2018

Scopus Subject Areas

  • Epidemiology
  • Infectious Diseases

User-Defined Keywords

  • China
  • HIV-1
  • molecular epidemiology
  • transmitted drug resistance
  • Yunnan

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