The biochemistry of blister fluid from pediatric burn injuries: Proteomics and metabolomics aspects

Tuo Zang, Daniel A. Broszczak, James A. Broadbent, Leila Cuttle, Haitao Lu, Tony J. Parker*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)

Abstract

Burn injury is a prevalent and traumatic event for pediatric patients. At present, the diagnosis of burn injury severity is subjective and lacks a clinically relevant quantitative measure. This is due in part to a lack of knowledge surrounding the biochemistry of burn injuries and that of blister fluid. A more complete understanding of the blister fluid biochemistry may open new avenues for diagnostic and prognostic development. Burn insult induces a highly complex network of signaling processes and numerous changes within various biochemical systems, which can ultimately be examined using proteome and metabolome measurements. This review reports on the current understanding of burn wound biochemistry and outlines a technical approach for 'omics' profiling of blister fluid from burn wounds of differing severity.

Original languageEnglish
Pages (from-to)35-53
Number of pages19
JournalExpert Review of Proteomics
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 2016

Scopus Subject Areas

  • Biochemistry
  • Molecular Biology

User-Defined Keywords

  • pediatric burns
  • proteomics
  • metabolomics
  • mass spectrometry
  • nuclear magnetic resonance
  • blister fluid

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