The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese

Man Wai Ng; Gangqiao Zhou; Wai Po Chong; Loretta Wing Yan Lee; Helen K.W. Law; Hongxing Zhang; Wilfred Hing Sang Wong; Susanna Fung Shan Fok; Yun Zhai; Raymond W.H. Yung; Eudora Y. Chow; Ka Leung Au; Eric Y.T. Chan; Wilina Lim; J. S.Malik Peiris; Fuchu He; Yu Lung Lau

doi:10.1186/1471-2334-7-50

The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese

Man Wai Ng, Gangqiao Zhou, Wai Po Chong, Loretta Wing Yan Lee, Helen K.W. Law, Hongxing Zhang, Wilfred Hing Sang Wong, Susanna Fung Shan Fok, Yun Zhai, Raymond W.H. Yung, Eudora Y. Chow, Ka Leung Au, Eric Y.T. Chan, Wilina Lim, J. S.Malik Peiris, Fuchu He, Yu Lung Lau^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

37 Citations (Scopus)

Abstract

Background: Chemokines play important roles in inflammation and antiviral action. We examined whether polymorphisms of RANTES, IP-10 and Mig affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS).

Methods: We tested the polymorphisms of RANTES, IP-10 and Mig for their associations with SARS in 495 Hong Kong Chinese SARS patients and 578 controls. Then we tried to confirm the results in 356 Beijing Chinese SARS patients and 367 controls.

Results: RANTES -28 G allele was associated with SARS susceptibility in Hong Kong Chinese (P < 0.0001, OR = 2.80, 95%CI:2.11-3.71). Individuals with RANTES -28 CG and GG genotypes had a 3.28-fold (95%CI:2.32-4.64) and 3.06-fold (95%CI:1.47-6.39) increased risk of developing SARS respectively (P < 0.0001). This -28 G allele conferred risk of death in a gene-dosage dependent manner (P = 0.014) with CG and GG individuals having a 2.12-fold (95% CI: 1.11-4.06) and 4.01-fold (95% CI: 1.30-12.4) increased risk. For the replication of RANTES data in Beijing Chinese, the -28 G allele was not associated with susceptibility to SARS. However, -28 CG (OR = 4.27, 95%CI:1.64-11.1) and GG (OR = 3.34, 95%CI:0.37-30.7) were associated with admission to intensive care units or death due to SARS (P = 0.011).

Conclusion: RANTES -28 G allele plays a role in the pathogenesis of SARS.

Original language	English
Article number	50
Number of pages	8
Journal	BMC Infectious Diseases
Volume	7
DOIs	https://doi.org/10.1186/1471-2334-7-50
Publication status	Published - 1 Jun 2007

Scopus Subject Areas

Infectious Diseases

User-Defined Keywords

Severe Acute Respiratory Syndrome
Severe Acute Respiratory Syndrome Patient
Death Group
Significant Single Nucleotide Polymorphism

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10.1186/1471-2334-7-50

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Ng, M. W., Zhou, G., Chong, W. P., Lee, L. W. Y., Law, H. K. W., Zhang, H., Wong, W. H. S., Fok, S. F. S., Zhai, Y., Yung, R. W. H., Chow, E. Y., Au, K. L., Chan, E. Y. T., Lim, W., Peiris, J. S. M., He, F., & Lau, Y. L. (2007). The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese. BMC Infectious Diseases, 7, Article 50. https://doi.org/10.1186/1471-2334-7-50

@article{f37a2bfd5e2e4230a686b4e4f7462c0c,

title = "The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese",

abstract = "Background: Chemokines play important roles in inflammation and antiviral action. We examined whether polymorphisms of RANTES, IP-10 and Mig affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS).Methods: We tested the polymorphisms of RANTES, IP-10 and Mig for their associations with SARS in 495 Hong Kong Chinese SARS patients and 578 controls. Then we tried to confirm the results in 356 Beijing Chinese SARS patients and 367 controls.Results: RANTES -28 G allele was associated with SARS susceptibility in Hong Kong Chinese (P < 0.0001, OR = 2.80, 95%CI:2.11-3.71). Individuals with RANTES -28 CG and GG genotypes had a 3.28-fold (95%CI:2.32-4.64) and 3.06-fold (95%CI:1.47-6.39) increased risk of developing SARS respectively (P < 0.0001). This -28 G allele conferred risk of death in a gene-dosage dependent manner (P = 0.014) with CG and GG individuals having a 2.12-fold (95% CI: 1.11-4.06) and 4.01-fold (95% CI: 1.30-12.4) increased risk. For the replication of RANTES data in Beijing Chinese, the -28 G allele was not associated with susceptibility to SARS. However, -28 CG (OR = 4.27, 95%CI:1.64-11.1) and GG (OR = 3.34, 95%CI:0.37-30.7) were associated with admission to intensive care units or death due to SARS (P = 0.011).Conclusion: RANTES -28 G allele plays a role in the pathogenesis of SARS.",

keywords = "Severe Acute Respiratory Syndrome, Severe Acute Respiratory Syndrome Patient, Death Group, Significant Single Nucleotide Polymorphism",

author = "Ng, {Man Wai} and Gangqiao Zhou and Chong, {Wai Po} and Lee, {Loretta Wing Yan} and Law, {Helen K.W.} and Hongxing Zhang and Wong, {Wilfred Hing Sang} and Fok, {Susanna Fung Shan} and Yun Zhai and Yung, {Raymond W.H.} and Chow, {Eudora Y.} and Au, {Ka Leung} and Chan, {Eric Y.T.} and Wilina Lim and Peiris, {J. S.Malik} and Fuchu He and Lau, {Yu Lung}",

year = "2007",

month = jun,

day = "1",

doi = "10.1186/1471-2334-7-50",

language = "English",

volume = "7",

journal = "BMC Infectious Diseases",

issn = "1471-2334",

publisher = "BioMed Central Ltd.",

}

TY - JOUR

T1 - The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese

AU - Ng, Man Wai

AU - Zhou, Gangqiao

AU - Chong, Wai Po

AU - Lee, Loretta Wing Yan

AU - Law, Helen K.W.

AU - Zhang, Hongxing

AU - Wong, Wilfred Hing Sang

AU - Fok, Susanna Fung Shan

AU - Zhai, Yun

AU - Yung, Raymond W.H.

AU - Chow, Eudora Y.

AU - Au, Ka Leung

AU - Chan, Eric Y.T.

AU - Lim, Wilina

AU - Peiris, J. S.Malik

AU - He, Fuchu

AU - Lau, Yu Lung

PY - 2007/6/1

Y1 - 2007/6/1

N2 - Background: Chemokines play important roles in inflammation and antiviral action. We examined whether polymorphisms of RANTES, IP-10 and Mig affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS).Methods: We tested the polymorphisms of RANTES, IP-10 and Mig for their associations with SARS in 495 Hong Kong Chinese SARS patients and 578 controls. Then we tried to confirm the results in 356 Beijing Chinese SARS patients and 367 controls.Results: RANTES -28 G allele was associated with SARS susceptibility in Hong Kong Chinese (P < 0.0001, OR = 2.80, 95%CI:2.11-3.71). Individuals with RANTES -28 CG and GG genotypes had a 3.28-fold (95%CI:2.32-4.64) and 3.06-fold (95%CI:1.47-6.39) increased risk of developing SARS respectively (P < 0.0001). This -28 G allele conferred risk of death in a gene-dosage dependent manner (P = 0.014) with CG and GG individuals having a 2.12-fold (95% CI: 1.11-4.06) and 4.01-fold (95% CI: 1.30-12.4) increased risk. For the replication of RANTES data in Beijing Chinese, the -28 G allele was not associated with susceptibility to SARS. However, -28 CG (OR = 4.27, 95%CI:1.64-11.1) and GG (OR = 3.34, 95%CI:0.37-30.7) were associated with admission to intensive care units or death due to SARS (P = 0.011).Conclusion: RANTES -28 G allele plays a role in the pathogenesis of SARS.

AB - Background: Chemokines play important roles in inflammation and antiviral action. We examined whether polymorphisms of RANTES, IP-10 and Mig affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS).Methods: We tested the polymorphisms of RANTES, IP-10 and Mig for their associations with SARS in 495 Hong Kong Chinese SARS patients and 578 controls. Then we tried to confirm the results in 356 Beijing Chinese SARS patients and 367 controls.Results: RANTES -28 G allele was associated with SARS susceptibility in Hong Kong Chinese (P < 0.0001, OR = 2.80, 95%CI:2.11-3.71). Individuals with RANTES -28 CG and GG genotypes had a 3.28-fold (95%CI:2.32-4.64) and 3.06-fold (95%CI:1.47-6.39) increased risk of developing SARS respectively (P < 0.0001). This -28 G allele conferred risk of death in a gene-dosage dependent manner (P = 0.014) with CG and GG individuals having a 2.12-fold (95% CI: 1.11-4.06) and 4.01-fold (95% CI: 1.30-12.4) increased risk. For the replication of RANTES data in Beijing Chinese, the -28 G allele was not associated with susceptibility to SARS. However, -28 CG (OR = 4.27, 95%CI:1.64-11.1) and GG (OR = 3.34, 95%CI:0.37-30.7) were associated with admission to intensive care units or death due to SARS (P = 0.011).Conclusion: RANTES -28 G allele plays a role in the pathogenesis of SARS.

KW - Severe Acute Respiratory Syndrome

KW - Severe Acute Respiratory Syndrome Patient

KW - Death Group

KW - Significant Single Nucleotide Polymorphism

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UR - http://europepmc.org/abstract/med/17540042

U2 - 10.1186/1471-2334-7-50

DO - 10.1186/1471-2334-7-50

M3 - Journal article

C2 - 17540042

SN - 1471-2334

VL - 7

JO - BMC Infectious Diseases

JF - BMC Infectious Diseases

M1 - 50

ER -

The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese

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