The antiviral effects of acteoside and the underlying IFN-γ-inducing action

Xun Song, Jiang He, Hong Xu, Xiao-Peng Hu, Xu-Li Wu, Hai-Qiang Wu, Li-Zhong Liu, Cheng-Hui Liao, Yong Zeng, Yan Li, Yue Hao, Chen-Shu Xu, Long Fan, Jian Zhang*, Hong-Jie Zhang*, Zhen-Dan He*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

42 Citations (Scopus)
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There are many herbal teas that are found in nature that may be effective at treating the symptoms and also shortening the duration of viral infections. When combating viral infections, T lymphocytes are an indispensable part of human acquired immunity. However, studies on the use of natural products in stimulating lymphocyte-mediated interferon-gamma (IFN-γ) production are very limited. In this study, we found that acteoside, a natural phenylpropanoid glycoside from Kuding Tea, enhanced IFN-γ production in mouse lymphocytes in a dose-dependent manner, particularly in the CD4+ and CD8+ subsets of T lymphocytes. To this end, we suggest that the antiviral activity of acteoside was highly correlated to its inducing ability of IFN-γ production. Mechanistically, the activation of T-bet enhanced the promoter of IFN-γ and subsequently resulted in an increased IFN-γ production in T cells. Collectively, we have found a natural product with the capacity to selectively enhance mouse T cell IFN-γ production. Given the role of IFN-γ in the immune system, further studies to clarify the role of acteoside in inducing IFN-γ and prevention of viral infection are needed.

Original languageEnglish
Pages (from-to)3017-3030
Number of pages14
JournalFood and Function
Issue number7
Early online date10 Jun 2016
Publication statusPublished - Jul 2016

Scopus Subject Areas

  • Food Science


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