The antipsychotics sulpiride induces fatty liver in rats via phosphorylation of insulin receptor substrate-1 at Serine 307-mediated adipose tissue insulin resistance

Keyphrases

• Phosphorylation 100%
• Antipsychotics 100%
• Fatty Liver 100%
• Insulin Receptor Substrate 1 (IRS1) 100%
• Sulpiride 100%
• Adipose Tissue Insulin Resistance 100%
• Metabolic Abnormalities 20%
• Insulin Resistance 10%
• Protein Expression 10%
• Oral Glucose Tolerance Test 10%
• Fatty Acid Composition 10%
• Developing Countries 10%
• MRNA Expression 10%
• Adipose Tissue 10%
• Gene Expression Profile 10%
• Co-treatment 10%
• Insulin Concentration 10%
• Once-daily 10%
• Dopamine D2 Receptor (DRD2) 10%
• Hyperprolactinemia 10%
• Bromocriptine 10%
• Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) 10%
• Fasting Insulin 10%
• Non-esterified Fatty Acids 10%
• Index Size 10%
• Steatotic 10%
• Chronic Administration 10%
• Adipocyte Size 10%
• Dopamine D2 Receptor Agonist 10%
• Hepatic Lipid Accumulation 10%
• Oil Red O 10%
• Insulin Resistance Index 10%
• Triglyceride Oil 10%
• IRS2 10%
• Free Fatty Acid Release 10%
• Adverse Metabolic Effects 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Insulin Resistance 100%
• Serine 100%
• Fatty Liver 100%
• Sulpiride 100%
• Insulin Receptor Substrate 1 100%
• Fatty Acid 20%
• Antipsychotic 20%
• Messenger RNA 10%
• Protein Kinase B 10%
• Triacylglycerol 10%
• Hyperprolactinemia 10%
• Bromocriptine 10%
• Dopamine Receptor D2 10%
• Insulin Receptor Substrate 2 10%
• Dopamine 2 Receptor Stimulating Agent 10%