The advantages of using Scutellaria baicalensis and its flavonoids for the management of non-viral hepatocellular carcinoma

Minting Chen, Haitao XIAO, Baisen Chen, Zhaoxiang BIAN*, Hiu Yee KWAN

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Scutellaria baicalensis Georgi is functional food and potential therapeutics for liver cancer. Among all the primary liver cancer, hepatocellular carcinoma (HCC) is the most common sub-type. The non-viral causes of HCC include diabetes mellitus (DM), non-alcoholic fatty liver disease (NAFLD), obesity, alcohol consumption and smoking. All these non-viral causes have pathogenic effects on HCC. Bioinformatics studies show that S. baicalensis acts on different targets in a complex signaling network in HCC. Experimental studies also suggested S. baicalensis and its flavonoids not only possess anti-HCC effects, but also alleviate the pathogenic conditions that are associated with the non-viral risk factors such as hepatic steatosis, NAFLD, DM and obesity. Therefore, S. baicalensis and its flavonoids have an advantage for the management of non-viral HCC. This review comprehensively summarizes the clinical application, therapeutic effects, mode of action at molecular levels and the safety of S. baicalensis and its flavonoids in HCC treatment.

Original languageEnglish
Article number104389
JournalJournal of Functional Foods
Volume78
DOIs
Publication statusPublished - Mar 2021

Scopus Subject Areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

User-Defined Keywords

  • Diabetes mellitus
  • Hepatocellular carcinoma
  • Non-alcoholic fatty liver disease
  • Obesity
  • Scutellaria baicalensis

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