TY - JOUR
T1 - The advantages of using Scutellaria baicalensis and its flavonoids for the management of non-viral hepatocellular carcinoma
AU - Chen, Minting
AU - Xiao, Haitao
AU - Chen, Baisen
AU - Bian, Zhaoxiang
AU - Kwan, Hiu Yee
N1 - Funding Information:
This work was partially supported by Shenzhen Science and Technology Innovation Committee Grant #JCYJ20170413170320959 to BZX; Research Grant Council of HKSAR HKBU-22103017-ECS, Innovation & Technology Commission #PRP/015/19FX, National Natural Science Foundation of China #SCM-2016-NSFC-003 and Natural Science Foundation of Guangdong Province #2018A0303130122 to HYK; Science and Technology Project of Shenzhen #JCYJ20160531193812867 to HQB.
Publisher copyright:
© 2021 The Author(s). Published by Elsevier Ltd.
PY - 2021/3
Y1 - 2021/3
N2 - Scutellaria baicalensis Georgi is functional food and potential therapeutics for liver cancer. Among all the primary liver cancer, hepatocellular carcinoma (HCC) is the most common sub-type. The non-viral causes of HCC include diabetes mellitus (DM), non-alcoholic fatty liver disease (NAFLD), obesity, alcohol consumption and smoking. All these non-viral causes have pathogenic effects on HCC. Bioinformatics studies show that S. baicalensis acts on different targets in a complex signaling network in HCC. Experimental studies also suggested S. baicalensis and its flavonoids not only possess anti-HCC effects, but also alleviate the pathogenic conditions that are associated with the non-viral risk factors such as hepatic steatosis, NAFLD, DM and obesity. Therefore, S. baicalensis and its flavonoids have an advantage for the management of non-viral HCC. This review comprehensively summarizes the clinical application, therapeutic effects, mode of action at molecular levels and the safety of S. baicalensis and its flavonoids in HCC treatment.
AB - Scutellaria baicalensis Georgi is functional food and potential therapeutics for liver cancer. Among all the primary liver cancer, hepatocellular carcinoma (HCC) is the most common sub-type. The non-viral causes of HCC include diabetes mellitus (DM), non-alcoholic fatty liver disease (NAFLD), obesity, alcohol consumption and smoking. All these non-viral causes have pathogenic effects on HCC. Bioinformatics studies show that S. baicalensis acts on different targets in a complex signaling network in HCC. Experimental studies also suggested S. baicalensis and its flavonoids not only possess anti-HCC effects, but also alleviate the pathogenic conditions that are associated with the non-viral risk factors such as hepatic steatosis, NAFLD, DM and obesity. Therefore, S. baicalensis and its flavonoids have an advantage for the management of non-viral HCC. This review comprehensively summarizes the clinical application, therapeutic effects, mode of action at molecular levels and the safety of S. baicalensis and its flavonoids in HCC treatment.
KW - Diabetes mellitus
KW - Hepatocellular carcinoma
KW - Non-alcoholic fatty liver disease
KW - Obesity
KW - Scutellaria baicalensis
UR - http://www.scopus.com/inward/record.url?scp=85101008579&partnerID=8YFLogxK
U2 - 10.1016/j.jff.2021.104389
DO - 10.1016/j.jff.2021.104389
M3 - Review article
AN - SCOPUS:85101008579
SN - 1756-4646
VL - 78
JO - Journal of Functional Foods
JF - Journal of Functional Foods
M1 - 104389
ER -
