TY - JOUR
T1 - Text Mining of Rheumatoid Arthritis and Diabetes Mellitus to Understand the Mechanisms of Chinese Medicine in Different Diseases with Same Treatment
AU - Zhao, Ning
AU - Zheng, Guang
AU - Li, Jian
AU - Zhao, Hong yan
AU - Lu, Cheng
AU - Jiang, Miao
AU - Zhang, Chi
AU - Guo, Hong tao
AU - Lu, Aiping
N1 - Funding Information:
©The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag Berlin Heidelberg 2018 Supported by the National Natural Science Foundation of China (No. 81573845, 81473367, 81403209, 30825047), China Academy of Chinese Medical Sciences Project (No. Z0412), and Beijing Nova Program (No. xx2014B073) 1. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing (100700), China; 2. School of Information Science and Engineering, Lanzhou University, Lanzhou (730000), China; 3. School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing (100029), China; 4. Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing (100700), China; 5. School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China Correspondence to: Prof. LU Ai-ping, Tel: 852-34112457, E-mail: [email protected] DOI: https://doi.org/10.1007/s11655-018-2825-x
PY - 2018/10
Y1 - 2018/10
N2 - Objective: To identify the commonalities between rheumatoid arthritis (RA) and diabetes mellitus (DM) to understand the mechanisms of Chinese medicine (CM) in different diseases with the same treatment. Methods: A text mining approach was adopted to analyze the commonalities between RA and DM according to CM and biological elements. The major commonalities were subsequently verified in RA and DM rat models, in which herbal formula for the treatment of both RA and DM identified via text mining was used as the intervention. Results: Similarities were identified between RA and DM regarding the CM approach used for diagnosis and treatment, as well as the networks of biological activities affected by each disease, including the involvement of adhesion molecules, oxidative stress, cytokines, T-lymphocytes, apoptosis, and inflammation. The Ramulus Cinnamomi-Radix Paeoniae Alba-Rhizoma Anemarrhenae is an herbal combination used to treat RA and DM. This formula demonstrated similar effects on oxidative stress and inflammation in rats with collagen-induced arthritis, which supports the text mining results regarding the commonalities between RA and DM. Conclusion: Commonalities between the biological activities involved in RA and DM were identified through text mining, and both RA and DM might be responsive to the same intervention at a specific stage.
AB - Objective: To identify the commonalities between rheumatoid arthritis (RA) and diabetes mellitus (DM) to understand the mechanisms of Chinese medicine (CM) in different diseases with the same treatment. Methods: A text mining approach was adopted to analyze the commonalities between RA and DM according to CM and biological elements. The major commonalities were subsequently verified in RA and DM rat models, in which herbal formula for the treatment of both RA and DM identified via text mining was used as the intervention. Results: Similarities were identified between RA and DM regarding the CM approach used for diagnosis and treatment, as well as the networks of biological activities affected by each disease, including the involvement of adhesion molecules, oxidative stress, cytokines, T-lymphocytes, apoptosis, and inflammation. The Ramulus Cinnamomi-Radix Paeoniae Alba-Rhizoma Anemarrhenae is an herbal combination used to treat RA and DM. This formula demonstrated similar effects on oxidative stress and inflammation in rats with collagen-induced arthritis, which supports the text mining results regarding the commonalities between RA and DM. Conclusion: Commonalities between the biological activities involved in RA and DM were identified through text mining, and both RA and DM might be responsive to the same intervention at a specific stage.
KW - Chinese medicine
KW - diabetes mellitus
KW - different diseases with same treatment
KW - rheumatoid arthritis
KW - text mining
UR - http://www.scopus.com/inward/record.url?scp=85040374712&partnerID=8YFLogxK
U2 - 10.1007/s11655-018-2825-x
DO - 10.1007/s11655-018-2825-x
M3 - Journal article
C2 - 29327123
AN - SCOPUS:85040374712
SN - 1672-0415
VL - 24
SP - 777
EP - 784
JO - Chinese Journal of Integrative Medicine
JF - Chinese Journal of Integrative Medicine
IS - 10
ER -
