TY - JOUR
T1 - Tetrazolyl Porphyrin-Based Hydrogen-Bonded Organic Frameworks
T2 - Active Sites-Mediated Host-Guest Synergy for Advanced Antimicrobial Applications
AU - Hou, Ya Jun
AU - Fang, Shuting
AU - Zhang, Xiao Yu
AU - Wang, Juan
AU - Ruan, Qijun
AU - Xiang, Zhangmin
AU - Wang, Zheng
AU - Zhu, Xun Jin
N1 - Funding Information:
This research was financially supported by the National Natural Science Foundation of China (22004113, 22101162), Guangdong Basic and Applied Basic Research Foundation (2019A1515110420), GDAS’ Special Project for Construction of Domestic First-Class Research Institutions (2021GDASYL-20210103034, 2020GDASYL-20200102007), Start-up Foundation of Shaanxi University of Science & Technology (126022036), and Open Foundation of MOE Key Laboratory of Bioinorganic and Synthetic Chemistry (BISC2021A04).
Publisher Copyright:
© 2022 American Chemical Society
PY - 2022/11/9
Y1 - 2022/11/9
N2 - Hydrogen-bonded organic frameworks (HOFs) with multiple functions and permanent pores have received widespread attention due to their potential applications in gas adsorption/separation, drug delivery, photocatalysis, proton conduction, and other fields. Herein, we constructed a three-dimensional (3D) HOF with 1D square channels by utilizing a dual-functional tetrazolyl porphyrin ligand bearing an active center of the porphyrin core and open sites of nitrogen atoms through π–π stacking and hydrogen-bonding interaction self-assembly. The structure exhibits both solvent resistance and thermal stability, and especially, maintains these after being transformed into nanoparticles. Meanwhile, the active sites exposed on the inner wall of the pores can interact well with the photoactive cationic dye molecules to form an effective host-guest (H-G) system, which can realize boosted photosensitized singlet oxygen (1O2) production under red light irradiation and synergistic sterilization toward Staphylococcus aureus (S. aureus) with an inhibition ratio as high as 99.9%. This work provides a valuable design concept for HOF-related systems in pursuit of promoted photoactivity.
AB - Hydrogen-bonded organic frameworks (HOFs) with multiple functions and permanent pores have received widespread attention due to their potential applications in gas adsorption/separation, drug delivery, photocatalysis, proton conduction, and other fields. Herein, we constructed a three-dimensional (3D) HOF with 1D square channels by utilizing a dual-functional tetrazolyl porphyrin ligand bearing an active center of the porphyrin core and open sites of nitrogen atoms through π–π stacking and hydrogen-bonding interaction self-assembly. The structure exhibits both solvent resistance and thermal stability, and especially, maintains these after being transformed into nanoparticles. Meanwhile, the active sites exposed on the inner wall of the pores can interact well with the photoactive cationic dye molecules to form an effective host-guest (H-G) system, which can realize boosted photosensitized singlet oxygen (1O2) production under red light irradiation and synergistic sterilization toward Staphylococcus aureus (S. aureus) with an inhibition ratio as high as 99.9%. This work provides a valuable design concept for HOF-related systems in pursuit of promoted photoactivity.
KW - dye adsorption
KW - HOFs
KW - host-guest system
KW - photoinduced 1O2 production
KW - synergistic sterilization
KW - tetrazolium porphyrin
UR - http://www.scopus.com/inward/record.url?scp=85141024358&partnerID=8YFLogxK
U2 - 10.1021/acsami.2c15869
DO - 10.1021/acsami.2c15869
M3 - Journal article
AN - SCOPUS:85141024358
SN - 1944-8244
VL - 14
SP - 49875
EP - 49885
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
IS - 44
ER -