Tetrazolyl Porphyrin-Based Hydrogen-Bonded Organic Frameworks: Active Sites-Mediated Host-Guest Synergy for Advanced Antimicrobial Applications

Ya Jun Hou, Shuting Fang, Xiao Yu Zhang, Juan Wang, Qijun Ruan, Zhangmin Xiang, Zheng Wang*, Xun Jin Zhu

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

5 Citations (Scopus)

Abstract

Hydrogen-bonded organic frameworks (HOFs) with multiple functions and permanent pores have received widespread attention due to their potential applications in gas adsorption/separation, drug delivery, photocatalysis, proton conduction, and other fields. Herein, we constructed a three-dimensional (3D) HOF with 1D square channels by utilizing a dual-functional tetrazolyl porphyrin ligand bearing an active center of the porphyrin core and open sites of nitrogen atoms through π–π stacking and hydrogen-bonding interaction self-assembly. The structure exhibits both solvent resistance and thermal stability, and especially, maintains these after being transformed into nanoparticles. Meanwhile, the active sites exposed on the inner wall of the pores can interact well with the photoactive cationic dye molecules to form an effective host-guest (H-G) system, which can realize boosted photosensitized singlet oxygen (1O2) production under red light irradiation and synergistic sterilization toward Staphylococcus aureus (S. aureus) with an inhibition ratio as high as 99.9%. This work provides a valuable design concept for HOF-related systems in pursuit of promoted photoactivity.

Original languageEnglish
Pages (from-to)49875–49885
Number of pages11
JournalACS Applied Materials and Interfaces
Volume14
Issue number44
DOIs
Publication statusPublished - 9 Nov 2022

Scopus Subject Areas

  • Materials Science(all)

User-Defined Keywords

  • dye adsorption
  • HOFs
  • host-guest system
  • photoinduced 1O2 production
  • synergistic sterilization
  • tetrazolium porphyrin

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