## Abstract

In this article, we investigate procedures for comparing two independent Poisson variates that are observed over unequal sampling frames (i.e. time intervals, populations, areas or any combination thereof). We consider two statistics (with and without the logarithmic transformation) for testing the equality of two Poisson rates. Two methods for implementing these statistics are reviewed. They are (1) the sample-based method, and (2) the constrained maximum likelihood estimation (CMLE) method. We conduct an empirical study to evaluate the performance of different statistics and methods. Generally, we find that the CMLE method works satisfactorily only for the statistic without the logarithmic transformation (denoted as W_{2}) while sample-based method performs better for the statistic using the logarithmic transformation (denoted as W_{3}). It is noteworthy that both statistics perform well for moderate to large Poisson rates (e.g. ≥10). For small Poisson rates (e.g. <10), W_{2} can be liberal (e.g. actual type I error rate/nominal level ≥1.2) while W_{3} can be conservative (e.g. actual type I error rate/nominal level ≤0.8). The corresponding sample size formulae are provided and valid in the sense that the simulated powers associated with the approximate sample size formulae are generally close to the pre-chosen power level. We illustrate our methodologies with a real example from a breast cancer study.

Original language | English |
---|---|

Pages (from-to) | 955-965 |

Number of pages | 11 |

Journal | Statistics in Medicine |

Volume | 24 |

Issue number | 6 |

DOIs | |

Publication status | Published - 30 Mar 2005 |

## Scopus Subject Areas

- Epidemiology
- Statistics and Probability

## User-Defined Keywords

- Constrained maximum likelihood estimation
- Sample size