Testing non-inferiority of a new treatment in three-arm clinical trials with binary endpoints

Keyphrases

• Clinical Trials 100%
• Non-inferiority Trial 100%
• Non-inferiority 100%
• Binary Endpoint 100%
• Small Sample Size 66%
• Type I Error Rate 66%
• Score Test Statistic 66%
• Placebo 66%
• Bootstrap Resampling Method 66%
• Noninferiority Margin 66%
• Three-arm Trial 66%
• Saddlepoint Approximation 66%
• Assay Sensitivity 66%
• Simulation Study 33%
• Error Power 33%
• Ethical Issues 33%
• Trial Design 33%
• Nominal Level 33%
• Likelihood Ratio Test 33%
• Wald 33%
• Experimental Therapeutics 33%
• Wald Statistic 33%
• Score Ratio 33%
• Asymptotic Methods 33%
• Approximation Methods 33%
• Binary Outcome 33%
• Design Analysis 33%
• Internal Validity 33%
• Large Sample Approach 33%
• Small Sample Method 33%
• Resampling Test 33%
• Bootstrap Resampling 33%

Mathematics

• Approximates 100%
• Test Statistic 66%
• Error Rate 66%
• Test Procedure 66%
• Score Test 66%
• Wald 66%
• Resampling Method 66%
• Inferiority Margin 66%
• Simulation Study 33%
• Type Test Statistic 33%
• Likelihood Ratio Test 33%
• Nominal Level 33%
• Asymptotic Analysis 33%
• Approximation Method 33%
• Trial Design 33%
• Saddle Point Approximation 33%
• Experimental Treatment 33%
• Arm Trial 33%
• Internal Validity 33%