Abstract
Tenacissimoside A (1) and 11α-O-benzoyl-12β-O-acetyltenacigenin B (2), two derivatives of tenacigenin B (3) from the plant Marsdenia tenacissima, reversed multidrug resistance in P-glycoprotein (Pgp)-overexpressing multidrug-resistant cancer cells. The sensitivity of HepG2/Dox cells to the antitumor drugs doxorubicin, vinblastine, puromycin, and paclitexel was increased by 18-, 10-, 11-, and 6-fold by 20 μg/mL (or 25 μM) of 1 and 16-, 53-, 16-, and 326-fold by 20 7mu;g/mL (or 39 μM) of 2, respectively. A preliminary mechanistic study has suggested that 1 might modulate Pgp-mediated multidrug resistance through directly interacting with the Pgp substrate site.
Original language | English |
---|---|
Pages (from-to) | 1049-1051 |
Number of pages | 3 |
Journal | Journal of Natural Products |
Volume | 71 |
Issue number | 6 |
DOIs | |
Publication status | Published - Jun 2008 |
Scopus Subject Areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry