Taurine Reverses Oxidative Damages and Restores the Muscle Function in Overuse of Exercised Muscle

Anand Thirupathi*, Ricardo A. Pinho, Julien Baker, Bíró István, Yaodong Gu*

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    22 Citations (Scopus)


    Exercise-induced oxidative stress is linked with the expression level of endogenous antioxidants, but these antioxidants cannot overcome all oxidative stress-related damages in the cells, particularly when cells are under physiological stress. Sometimes, compounds are needed for cellular function, which are produced/activated within the cells, and these compounds can be synthesized by performing exercise, especially high-performance exercise. Taurine is a sulfur-containing amino acid used for various physiological functions. However, its synthesis and accumulation under the oxidative environment may be compromised. Recently, we have shown that taurine level is increased during exercise performance with a decrease in oxidative damage in overused muscles. Other studies have also shown that short-term supplementation with taurine increased physiological performance during severe work intensities, suggesting the role of taurine in improving muscle performance during exercise. However, its precursor cysteine is used in the synthesis of other compounds like GSH and Coenzyme A, which are important for regulating the redox system and energy homeostasis. It is, therefore, important to understand whether taurine synthesis within the cells can blunt the activity of other compounds that are beneficial in preventing oxidative damage during intense exercise. Furthermore, it is important to understand whether taurine supplementation can prevent the conditions observed in the physiological stress of muscles. This review discusses how taurine synthesis could alter exercise-induced ROS generation and the relationship between the physiological stress of muscle and subsequent improvements in exercise performance.

    Original languageEnglish
    Article number582449
    JournalFrontiers in Physiology
    Publication statusPublished - 26 Oct 2020

    Scopus Subject Areas

    • Physiology
    • Physiology (medical)

    User-Defined Keywords

    • antioxidants
    • exercise
    • muscle overuse
    • oxidative stress
    • taurine


    Dive into the research topics of 'Taurine Reverses Oxidative Damages and Restores the Muscle Function in Overuse of Exercised Muscle'. Together they form a unique fingerprint.

    Cite this