Targeting testis-specific proteins to inhibit spermatogenesis: Lesson from endocrine disrupting chemicals

H. T. Wan, Dolores D. Mruk, Chris K C WONG, C. Yan Cheng*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

55 Citations (Scopus)


Introduction: Exposure to endocrine disrupting chemicals (EDCs) has recently been linked to declining fertility in men in both developed and developing countries. Since many EDCs possess intrinsic estrogenic or androgenic activities, thus, the gonad is one of the major targets of EDCs. Areas covered: For the past 2 decades, studies found in the literature regarding the disruptive effects of these EDCs on reproductive function in human males and also rodents were mostly focused on oxidative stress-induced germ cell apoptosis, disruption of steroidogenesis, abnormal sperm production and disruption of spermatogenesis in particular cell adhesion function and the blood-testis-barrier (BTB) function. Herein, we highlight recent findings in the field illustrating testis-specific proteins are also targets of EDCs. Expert opinion: This information should be helpful in developing better therapeutic approach to manage ECD-induced reproductive toxicity. This information is also helpful to identify potential targets for male contraceptive development.

Original languageEnglish
Pages (from-to)839-855
Number of pages17
JournalExpert Opinion on Therapeutic Targets
Issue number7
Publication statusPublished - Jul 2013

Scopus Subject Areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

User-Defined Keywords

  • Blood-testis-barrier
  • Endocrine disrupting chemicals
  • Spermatogenesis
  • Steroidogenesis
  • Testis
  • Testis-specific proteins


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