Targeting senescent immune cells to rejuvenate the aging skeleton

Ge Zhang*, Jin Liu

*Corresponding author for this work

Research output: Contribution to journalEditorial

Abstract

Accumulation of senescent cells in the bone marrow leads to age-related bone degeneration. Identifying the key senescent cell types and the factors they release that are responsible for skeletal aging is of keen interest. In a new study by Li et al. (2021), it is shown that immune cells, including neutrophils and macrophages, are critical cell types in this aging process, and that they secrete grancalcin to promote such aging.
Original languageEnglish
Pages (from-to)1903-1905
Number of pages3
JournalCell Metabolism
Volume33
Issue number10
DOIs
Publication statusPublished - 5 Oct 2021

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