Targeting ferroptosis to treat colorectal cancer

Hong Yan; Ronan Talty; Caroline H. Johnson

doi:10.1016/j.tcb.2022.11.003

Targeting ferroptosis to treat colorectal cancer

Hong Yan
, Ronan Talty
, Caroline H. Johnson^*

^*Corresponding author for this work

Department of Biology

Research output: Contribution to journal › Journal article › peer-review

122 Citations (Scopus)

Abstract

Ferroptosis has emerged as a promising target for colorectal cancer (CRC) treatment. Although disrupting glutathione metabolism is the primary strategy for ferroptosis induction, additional key pathways link ferroptosis to CRC pathogenesis. Here, we discuss arachidonic acid (AA), energy metabolism, AMP-activated protein kinase (AMPK), phosphatidylinositol-3-kinase (PI3K)-protein kinase B (Akt)-mammalian target of rapamycin (mTOR), and Hippo signaling, summarize key findings, and propose new conceptual avenues for CRC treatment.

Original language	English
Pages (from-to)	185-188
Number of pages	4
Journal	Trends in Cell Biology
Volume	33
Issue number	3
DOIs	https://doi.org/10.1016/j.tcb.2022.11.003
Publication status	Published - Mar 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

User-Defined Keywords

ferroptosis
colorectal cancer
metabolism
therapy

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10.1016/j.tcb.2022.11.003

Cite this

@article{e8b6f14ed07f43bcbbcafe4c023e59aa,

title = "Targeting ferroptosis to treat colorectal cancer",

abstract = "Ferroptosis has emerged as a promising target for colorectal cancer (CRC) treatment. Although disrupting glutathione metabolism is the primary strategy for ferroptosis induction, additional key pathways link ferroptosis to CRC pathogenesis. Here, we discuss arachidonic acid (AA), energy metabolism, AMP-activated protein kinase (AMPK), phosphatidylinositol-3-kinase (PI3K)-protein kinase B (Akt)-mammalian target of rapamycin (mTOR), and Hippo signaling, summarize key findings, and propose new conceptual avenues for CRC treatment.",

keywords = "ferroptosis, colorectal cancer, metabolism, therapy",

author = "Hong Yan and Ronan Talty and Johnson, \{Caroline H.\}",

note = "This work was supported by funding from the American Cancer Society Research Scholar Grant 134273-RSG-20-065-01-TBE (C.H.J.), NIH/NCI under Award NumberK12CA215110, and the NIH/NCI Yale SPORE in Skin Cancer under award number 5P50CA121974. R.T. is supported by NIH/NCI F30CA254246. Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd. All rights reserved.",

year = "2023",

month = mar,

doi = "10.1016/j.tcb.2022.11.003",

language = "English",

volume = "33",

pages = "185--188",

journal = "Trends in Cell Biology",

issn = "0962-8924",

publisher = "Elsevier Ltd.",

number = "3",

}

TY - JOUR

T1 - Targeting ferroptosis to treat colorectal cancer

AU - Yan, Hong

AU - Talty, Ronan

AU - Johnson, Caroline H.

N1 - This work was supported by funding from the American Cancer Society Research Scholar Grant 134273-RSG-20-065-01-TBE (C.H.J.), NIH/NCI under Award NumberK12CA215110, and the NIH/NCI Yale SPORE in Skin Cancer under award number 5P50CA121974. R.T. is supported by NIH/NCI F30CA254246. Publisher Copyright: © 2022 Elsevier Ltd. All rights reserved.

PY - 2023/3

Y1 - 2023/3

N2 - Ferroptosis has emerged as a promising target for colorectal cancer (CRC) treatment. Although disrupting glutathione metabolism is the primary strategy for ferroptosis induction, additional key pathways link ferroptosis to CRC pathogenesis. Here, we discuss arachidonic acid (AA), energy metabolism, AMP-activated protein kinase (AMPK), phosphatidylinositol-3-kinase (PI3K)-protein kinase B (Akt)-mammalian target of rapamycin (mTOR), and Hippo signaling, summarize key findings, and propose new conceptual avenues for CRC treatment.

AB - Ferroptosis has emerged as a promising target for colorectal cancer (CRC) treatment. Although disrupting glutathione metabolism is the primary strategy for ferroptosis induction, additional key pathways link ferroptosis to CRC pathogenesis. Here, we discuss arachidonic acid (AA), energy metabolism, AMP-activated protein kinase (AMPK), phosphatidylinositol-3-kinase (PI3K)-protein kinase B (Akt)-mammalian target of rapamycin (mTOR), and Hippo signaling, summarize key findings, and propose new conceptual avenues for CRC treatment.

KW - ferroptosis

KW - colorectal cancer

KW - metabolism

KW - therapy

UR - https://www.sciencedirect.com/science/article/pii/S0962892422002549?via%3Dihub

U2 - 10.1016/j.tcb.2022.11.003

DO - 10.1016/j.tcb.2022.11.003

M3 - Journal article

SN - 0962-8924

VL - 33

SP - 185

EP - 188

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 3

ER -

Targeting ferroptosis to treat colorectal cancer

Abstract

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