Targeted pH switched europium complexes monitoring receptor internalisation in living cells

Jack D. Fradgley, Matthieu Starck, Michel Laget, Emmanuel Bourrier, Elodie Dupuis, Laurent Lamarque, Eric Trinquet, Jurriaan M. Zwier, David Parker*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

10 Citations (Scopus)

Abstract

We report the design and evaluation of pH responsive luminescent europium(III) probes that allow conjugation to targeting vectors to monitor receptor internalisation in cells. The approach adopted here can be used to tag proteins selectively and to monitor uptake into more acidic organelles, thereby enhancing the performance of time-resolved internalisation assays that require pH monitoring in real time.
Original languageEnglish
Pages (from-to)5814-5817
Number of pages4
JournalChemical Communications
Volume57
Issue number47
Early online date4 May 2021
DOIs
Publication statusPublished - 14 Jun 2021

Scopus Subject Areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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