Targeted overexpression of the long noncoding RNA ODSM can regulate osteoblast function in vitro and in vivo

Yixuan Wang, Ke Wang, Lijun Zhang, Yingjun Tan, Zebing Hu, Lei Dang, Hua Zhou, Gaozhi Li, Han Wang, Shu Zhang, Fei Shi*, Xinsheng Cao, Ge ZHANG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Ameliorating bone loss caused by mechanical unloading is a substantial clinical challenge, and the role of noncoding RNAs in this process has attracted increasing attention. In this study, we found that the long noncoding RNA osteoblast differentiation-related lncRNA under simulated microgravity (lncRNA ODSM) could inhibit osteoblast apoptosis and promote osteoblast mineralization in vitro. The increased expression level of the lncRNA ODSM partially reduced apoptosis and promoted differentiation in MC3T3-E1 cells under microgravity unloading conditions, and the effect was partially dependent on miR-139-3p. LncRNA ODSM supplementation in hindlimb-unloaded mice caused a decrease in the number of apoptotic cells in bone tissue and an increase in osteoblast activity. Furthermore, targeted overexpression of the lncRNA ODSM in osteoblasts partially reversed bone loss induced by mechanical unloading at the microstructural and biomechanical levels. These findings are the first to suggest the potential value of the lncRNA ODSM in osteoporosis therapy and the treatment of pathological osteopenia.

Original languageEnglish
Article number133
JournalCell Death and Disease
Volume11
Issue number2
DOIs
Publication statusPublished - 1 Feb 2020

Scopus Subject Areas

  • Immunology
  • Cellular and Molecular Neuroscience
  • Cell Biology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Targeted overexpression of the long noncoding RNA ODSM can regulate osteoblast function in vitro and in vivo'. Together they form a unique fingerprint.

Cite this