Targeted delivery systems for molecular therapy in skeletal disorders

Lei Dang, Jin LIU, Fangfei LI, Luyao Wang, Defang LI, Baosheng GUO, Xiaojuan He, Feng Jiang, Chao LIANG, Biao Liu, Shaikh Atik Badshah, Bing He, Jun Lu, Cheng Lu, Aiping LYU*, Ge ZHANG

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

26 Citations (Scopus)

Abstract

Abnormalities in the integral components of bone, including bone matrix, bone mineral and bone cells, give rise to complex disturbances of skeletal development, growth and homeostasis. Non-specific drug delivery using high-dose systemic administration may decrease therapeutic efficacy of drugs and increase the risk of toxic effects in non-skeletal tissues, which remain clinical challenges in the treatment of skeletal disorders. Thus, targeted delivery systems are urgently needed to achieve higher drug delivery efficiency, improve therapeutic efficacy in the targeted cells/tissues, and minimize toxicities in non-targeted cells/tissues. In this review, we summarize recent progress in the application of different targeting moieties and nanoparticles for targeted drug delivery in skeletal disorders, and also discuss the advantages, challenges and perspectives in their clinical translation.

Original languageEnglish
Article number428
JournalInternational Journal of Molecular Sciences
Volume17
Issue number3
DOIs
Publication statusPublished - 22 Mar 2016

Scopus Subject Areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

User-Defined Keywords

  • Nanoparticles
  • Skeletal disorders
  • Targeted delivery systems
  • Targeting moieties

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