Systems Pharmacology-Based Strategy to Explore the Pharmacological Mechanisms of Citrus Peel (Chenpi) for Treating Complicated Diseases

Wei Zhou, Ziyi Chen, Aiping LYU, Zhigang Liu

Research output: Contribution to journalArticlepeer-review

Abstract

Citri Reticulatae Pericarpium (CRP), also known as Chenpi in Chinese, is the dry mature peel of Citrus reticulata Blanco or its cultivated varieties. CRP as the health-care food and dietary supplement has been widely used in various diseases. However, the potential pharmacological mechanisms of CRP to predict and treat various diseases have not yet been fully elucidated. A systems pharmacology-based approach is developed by integrating absorption, distribution, metabolism, and excretion screening, multiple target fishing, network pharmacology, as well as pathway analysis to comprehensively dissect the potential mechanism of CRP for therapy of various diseases. The results showed that 39 bioactive components and 121 potential protein targets were identified from CRP. The 121 targets are closely related to various diseases of the cardiovascular system, respiratory system, gastrointestinal system, etc. These targets are further mapped to compound-target, target-disease, and target-pathway networks to clarify the therapeutic mechanism of CRP at the system level. The current study sheds light on a promising way for promoting the discovery of new botanical drugs.

Original languageEnglish
Pages (from-to)391-411
Number of pages21
JournalAmerican Journal of Chinese Medicine
Volume49
Issue number02
DOIs
Publication statusPublished - 2021

Scopus Subject Areas

  • Complementary and alternative medicine

User-Defined Keywords

  • active compounds
  • Chenpi
  • Citri Reticulatae Pericarpium
  • complex diseases
  • pharmacological mechanisms
  • review
  • systems pharmacology

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