@article{7ff0ec3aa73b4c3ea0d4a178bead52a8,
title = "Systemic Study on the Biogenic Pathways of Yezo{\textquoteright}otogirins: Total Synthesis and Antitumor Activities of (±)-Yezo{\textquoteright}otogirin C and Its Structural Analogues",
abstract = "A systematic study of the biomimetic pathways to yezootogirin C under aerobic and anaerobic conditions has been investigated, and both are found to be feasible pathways to the natural product depending on the physiological conditions. Because of the lower activation energy, the aerobic process would be more favorable when the in vivo oxygen level is high. In the course of this study, a highly efficient synthetic route to (±)-yezootogirin C has been established in four steps (31% overall yield) from a readily available compound without using any protecting groups. The natural product and its structural analogues exhibited antitumor activities against several human cancer cell lines and appeared to arrest cell cycles in different phases.",
author = "Wei Yang and Jingming Cao and Mengxun Zhang and Rongfeng Lan and Lizhi Zhu and Guangyan Du and Shuzhong He and Lee, {Chi Sing}",
note = "We gratefully thank the NSFC (National Natural Science Foundation of China, No. 21272012), the SSTIC (Shenzhen Science and Technology Innovation Committee, KQTD201103 and ZDSY20120614144410389), and Peking University Shenzhen Graduate School for financial support. We also thank Prof. Hon-Wah Michael Lam (City University of Hong Kong) for proofreading this manuscript and Prof. Tao Wang (Southern University of Science and Technology) for solving the X-ray structures of 8 and 9. Publisher Copyright: {\textcopyright} 2014 American Chemical Society.",
year = "2015",
month = jan,
day = "16",
doi = "10.1021/jo502267g",
language = "English",
volume = "80",
pages = "836--846",
journal = "Journal of Organic Chemistry",
issn = "0022-3263",
publisher = "American Chemical Society",
number = "2",
}
