Synthesis, singlet-oxygen photogeneration, two-photon absorption, photo-induced DNA cleavage and cytotoxic properties of an amphiphilic β-Schiff-base linked Ru(II) polypyridyl-porphyrin conjugate

Hanzhong Ke*, Wanpeng Ma, Hongda Wang, Guoe Cheng, Han Yuan, Rick W K WONG, Daniel W J KWONG, Hoi Lam TAM, Kok Wai CHEAH, Chi Fai Chan, Ka-Leung WONG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

A novel porphyrin-polypyridyl ruthenium(II) conjugate (TPP-Ru), in which the ruthenium(II) polypyridyl moiety is linked to the β-position of the tetraphenylporphyrin via a Schiff base linkage, has been synthesized and characterized by 1H NMR, HRMS and UV-visible spectroscopy. The relative singlet oxygen quantum yield and two-photon absorption cross-section of this conjugate, together with its photo-induced DNA cleavage and cytotoxic activities were measured. The results show that the amphiphilic ruthenium(II) polypyridyl-porphyrin conjugate is an effective DNA photocleavage agent, with potential application in one- and two-photon absorption anti-cancer photodynamic therapy.

Original languageEnglish
Pages (from-to)356-361
Number of pages6
JournalJournal of Luminescence
Volume154
DOIs
Publication statusPublished - Oct 2014

Scopus Subject Areas

  • Biophysics
  • Biochemistry
  • Chemistry(all)
  • Atomic and Molecular Physics, and Optics
  • Condensed Matter Physics

User-Defined Keywords

  • DNA cleavage
  • in vitro imaging
  • Photodynamic therapy agents
  • Porphyrin

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