@article{401e363898334e52bfa8cbbdca0e36fc,
title = "Synthesis of the Tricyclic Picrotoxane Motif by an Oxidative Cascade Cyclization",
abstract = "An oxidative cascade cyclization of β-keto esters has been developed for the construction of the tricyclic picrotoxane motif in a single step, and DFT calculations suggested a possible cationic cyclization mechanism. This cascade cyclization can be operated on a 20 g scale to obtain a 77% total yield of the tricyclic products, which in turn can be converted to versatile intermediates for further elaboration to picrotoxanes and their structurally related compounds.",
author = "Jingming Cao and Waygen Thor and Shenkun Yang and Mengxun Zhang and Wenli Bao and Lizhi Zhu and Wei Yang and Cheng, {Yuen Kit} and Lee, {Chi Sing}",
note = "Funding Information: We gratefully acknowledge the National Natural Science Foundation of China (Grants 21502002, 21572006, and 21871017), the Natural Science Foundation of Guangdong Province, China (Grant 2017A030313042), the Shenzhen Science and Technology Innovation Committee (Grants JCYJ20160428153421635 and JCYJ20160330095659560), and Peking University Shenzhen Graduate School and Hong Kong Baptist University (RC-SGT2/18-19/SCI/005) for financial support. A special acknowledgement is made to Dr. Wesley Ting-kwok Chan (Hong Kong Polytechnic University) for the X-ray crystallography characterization of compounds (±)-15. Publisher copyright: {\textcopyright} 2019 American Chemical Society",
year = "2019",
month = jun,
day = "21",
doi = "10.1021/acs.orglett.9b01806",
language = "English",
volume = "21",
pages = "4896--4899",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "12",
}