Synthesis of the central C18–C30 core of the phorboxazole natural products

Chi Sing Lee; Craig J. Forsyth

doi:10.1016/0040-4039(96)01435-9

Synthesis of the central C18–C30 core of the phorboxazole natural products

Chi Sing Lee
, Craig J. Forsyth^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

64 Citations (Scopus)

Abstract

A direct synthesis of the central C18-C30 core of the phorboxazole natural products has been developed. This involves construction of an acyclic acrylate using Paterson's (E)-enol borinate aldol methodology followed by an intramolecular hetero-Michael addition to form the central pyran ring of the natural products.

Original language	English
Pages (from-to)	6449-6452
Number of pages	4
Journal	Tetrahedron Letters
Volume	37
Issue number	36
DOIs	https://doi.org/10.1016/0040-4039(96)01435-9
Publication status	Published - 2 Sept 1996

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10.1016/0040-4039(96)01435-9

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title = "Synthesis of the central C18–C30 core of the phorboxazole natural products",

abstract = "A direct synthesis of the central C18-C30 core of the phorboxazole natural products has been developed. This involves construction of an acyclic acrylate using Paterson's (E)-enol borinate aldol methodology followed by an intramolecular hetero-Michael addition to form the central pyran ring of the natural products.",

author = "Lee, \{Chi Sing\} and Forsyth, \{Craig J.\}",

note = "Publisher Copyright: {\textcopyright} 1996 Elsevier Science Ltd. Funding Information: We thank the University of Minnesota for a McKnight Land-Grant Professorship (CJF) for partial financial support, and Russell D. Cink and Feryan Ahmed for technical assistance.",

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AU - Lee, Chi Sing

AU - Forsyth, Craig J.

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PY - 1996/9/2

Y1 - 1996/9/2

N2 - A direct synthesis of the central C18-C30 core of the phorboxazole natural products has been developed. This involves construction of an acyclic acrylate using Paterson's (E)-enol borinate aldol methodology followed by an intramolecular hetero-Michael addition to form the central pyran ring of the natural products.

AB - A direct synthesis of the central C18-C30 core of the phorboxazole natural products has been developed. This involves construction of an acyclic acrylate using Paterson's (E)-enol borinate aldol methodology followed by an intramolecular hetero-Michael addition to form the central pyran ring of the natural products.

UR - https://www.scopus.com/pages/publications/0030565511

U2 - 10.1016/0040-4039(96)01435-9

DO - 10.1016/0040-4039(96)01435-9

M3 - Journal article

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SN - 0040-4039

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SP - 6449

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 36

ER -

Synthesis of the central C18–C30 core of the phorboxazole natural products

Abstract

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