Synthesis of novel diselenide-linked porphyrin dimers under phase-transfer catalysis condition and their interactions with DNA

Zhi Xue, Daniel Wei Jing Kwong, Ling Wei Xue, Qing Liu, An Xin Hou*, Wai Kwok Wong

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

6 Citations (Scopus)

Abstract

Novel diselenide-linked porphyrin dimers were synthesized under phase-transfer catalysis conditions. The targeted compounds were characterized by 1H-NMR, high-resolution mass spectrometry, UV/VIS and fluorescence spectroscopies, redox-potential measurements, and elemental analysis. The interaction of the title compounds with DNA was studied using UV/VIS, fluorescence, and circular dichroism (CD) spectroscopies. The relative rates of singlet-oxygen production from the diselenide-linked porphyrin dimers upon photoirradiation were also measured.

Original languageEnglish
Pages (from-to)1131-1143
Number of pages13
JournalChemistry and Biodiversity
Volume6
Issue number7
DOIs
Publication statusPublished - Jul 2009

Scopus Subject Areas

  • Bioengineering
  • Biochemistry
  • General Chemistry
  • Molecular Medicine
  • Molecular Biology

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