Synthesis of highly substituted indene derivatives by Brønsted acid catalyzed Friedel-Crafts reaction of homoallylic alcohols

Xiaoxiang Zhang; Wan Teng Teo; Weidong Rao; Dik Lung Ma; Chung Hang Leung; Philip Wai Hong Chan

doi:10.1016/j.tetlet.2014.05.027

Synthesis of highly substituted indene derivatives by Brønsted acid catalyzed Friedel-Crafts reaction of homoallylic alcohols

Xiaoxiang Zhang^*
, Wan Teng Teo
, Weidong Rao
, Dik Lung Ma
, Chung Hang Leung
, Philip Wai Hong Chan

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

25 Citations (Scopus)

Abstract

An efficient synthetic method to prepare highly substituted indenes in moderate to excellent yields that relies on Brønsted acid catalyzed Friedel-Crafts reaction of homoallylic alcohols under mild conditions is described.

Original language	English
Pages (from-to)	3881-3884
Number of pages	4
Journal	Tetrahedron Letters
Volume	55
Issue number	29
DOIs	https://doi.org/10.1016/j.tetlet.2014.05.027
Publication status	Published - 16 Jul 2014

User-Defined Keywords

Brønsted acid
Friedel-Crafts reaction
Homoallylic alcohols
Homogeneous catalysis
Indene derivatives

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10.1016/j.tetlet.2014.05.027

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@article{36e1d47d72f6417b856ad1c7d3ac5276,

title = "Synthesis of highly substituted indene derivatives by Br{\o}nsted acid catalyzed Friedel-Crafts reaction of homoallylic alcohols",

abstract = "An efficient synthetic method to prepare highly substituted indenes in moderate to excellent yields that relies on Br{\o}nsted acid catalyzed Friedel-Crafts reaction of homoallylic alcohols under mild conditions is described.",

keywords = "Br{\o}nsted acid, Friedel-Crafts reaction, Homoallylic alcohols, Homogeneous catalysis, Indene derivatives",

author = "Xiaoxiang Zhang and Teo, \{Wan Teng\} and Weidong Rao and Ma, \{Dik Lung\} and Leung, \{Chung Hang\} and Chan, \{Philip Wai Hong\}",

note = "Funding Information: This work is supported by a College of Science Start-Up Grant from Nanyang Technological University and a Tier 1 Grant ( MOE2013-T1-002-035 ) from the Ministry of Education of Singapore (to P.W.H.C.), a Young National Natural Science Foundation of China Grant (No. 21302096 ), a Young Natural Science Foundation of Jiangsu Province Grant ( BK20130962 ) and a Project Fund from the Priority Academic Program Development of Jiangsu Higher Education Institutions (to X.Z.). A Yousef Jameel Scholarship (to W.T.T.) is also gratefully acknowledged. ",

year = "2014",

month = jul,

day = "16",

doi = "10.1016/j.tetlet.2014.05.027",

language = "English",

volume = "55",

pages = "3881--3884",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd.",

number = "29",

}

TY - JOUR

T1 - Synthesis of highly substituted indene derivatives by Brønsted acid catalyzed Friedel-Crafts reaction of homoallylic alcohols

AU - Zhang, Xiaoxiang

AU - Teo, Wan Teng

AU - Rao, Weidong

AU - Ma, Dik Lung

AU - Leung, Chung Hang

AU - Chan, Philip Wai Hong

N1 - Funding Information: This work is supported by a College of Science Start-Up Grant from Nanyang Technological University and a Tier 1 Grant ( MOE2013-T1-002-035 ) from the Ministry of Education of Singapore (to P.W.H.C.), a Young National Natural Science Foundation of China Grant (No. 21302096 ), a Young Natural Science Foundation of Jiangsu Province Grant ( BK20130962 ) and a Project Fund from the Priority Academic Program Development of Jiangsu Higher Education Institutions (to X.Z.). A Yousef Jameel Scholarship (to W.T.T.) is also gratefully acknowledged.

PY - 2014/7/16

Y1 - 2014/7/16

N2 - An efficient synthetic method to prepare highly substituted indenes in moderate to excellent yields that relies on Brønsted acid catalyzed Friedel-Crafts reaction of homoallylic alcohols under mild conditions is described.

AB - An efficient synthetic method to prepare highly substituted indenes in moderate to excellent yields that relies on Brønsted acid catalyzed Friedel-Crafts reaction of homoallylic alcohols under mild conditions is described.

KW - Brønsted acid

KW - Friedel-Crafts reaction

KW - Homoallylic alcohols

KW - Homogeneous catalysis

KW - Indene derivatives

UR - https://www.scopus.com/pages/publications/84903273619

U2 - 10.1016/j.tetlet.2014.05.027

DO - 10.1016/j.tetlet.2014.05.027

M3 - Journal article

AN - SCOPUS:84903273619

SN - 0040-4039

VL - 55

SP - 3881

EP - 3884

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 29

ER -

Synthesis of highly substituted indene derivatives by Brønsted acid catalyzed Friedel-Crafts reaction of homoallylic alcohols

Abstract

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