Synthesis of functional building blocks for type III-B rotaxane dendrimer

Chak Shing Kwan, Watson K.W. Ho, Yanyan Chen, Zongwei Cai, Ken Cham Fai Leung*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review


Second-generation type III-B rotaxane dendrons, equipped with succinimide and acetylene functional groups, were synthesized successfully and characterized by NMR spectroscopy and mass spectrometry. A cell viability study of a dendron with a normal cell line of L929 fibroblast cells revealed no obvious cytotoxicity at a range of 5 to 100 µM. The nontoxic properties of the sophisticated rotaxane dendron building blocks provided a choice of bio-compatible macromolecular machines that could be potentially developed into polymeric materials.

Original languageEnglish
Article number3909
Pages (from-to)8
Issue number22
Publication statusPublished - 12 Nov 2021

Scopus Subject Areas

  • Chemistry(all)
  • Polymers and Plastics

User-Defined Keywords

  • Crown ether
  • Fibroblast
  • Functional dendron
  • Macromolecular machine
  • Rotaxane dendrimer


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