Synthesis of functional building blocks for type III-B rotaxane dendrimer

Chak Shing Kwan; Watson K.W. Ho; Yanyan Chen; Zongwei Cai; Ken Cham Fai Leung

doi:10.3390/polym13223909

Synthesis of functional building blocks for type III-B rotaxane dendrimer

Chak Shing Kwan, Watson K.W. Ho, Yanyan Chen, Zongwei Cai, Ken Cham Fai Leung^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

Abstract

Second-generation type III-B rotaxane dendrons, equipped with succinimide and acetylene functional groups, were synthesized successfully and characterized by NMR spectroscopy and mass spectrometry. A cell viability study of a dendron with a normal cell line of L929 fibroblast cells revealed no obvious cytotoxicity at a range of 5 to 100 µM. The nontoxic properties of the sophisticated rotaxane dendron building blocks provided a choice of bio-compatible macromolecular machines that could be potentially developed into polymeric materials.

Original language	English
Article number	3909
Pages (from-to)	8
Journal	Polymers
Volume	13
Issue number	22
DOIs	https://doi.org/10.3390/polym13223909
Publication status	Published - 12 Nov 2021

Scopus Subject Areas

General Chemistry
Polymers and Plastics

User-Defined Keywords

Crown ether
Fibroblast
Functional dendron
Macromolecular machine
Rotaxane dendrimer

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10.3390/polym13223909

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title = "Synthesis of functional building blocks for type III-B rotaxane dendrimer",

abstract = "Second-generation type III-B rotaxane dendrons, equipped with succinimide and acetylene functional groups, were synthesized successfully and characterized by NMR spectroscopy and mass spectrometry. A cell viability study of a dendron with a normal cell line of L929 fibroblast cells revealed no obvious cytotoxicity at a range of 5 to 100 µM. The nontoxic properties of the sophisticated rotaxane dendron building blocks provided a choice of bio-compatible macromolecular machines that could be potentially developed into polymeric materials.",

keywords = "Crown ether, Fibroblast, Functional dendron, Macromolecular machine, Rotaxane dendrimer",

author = "Kwan, {Chak Shing} and Ho, {Watson K.W.} and Yanyan Chen and Zongwei Cai and Leung, {Ken Cham Fai}",

note = "Funding Information: Funding: We acknowledge the financial support partially by The Hong Kong Baptist University (RC-KRPS-20-21/02). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = nov,

day = "12",

doi = "10.3390/polym13223909",

language = "English",

volume = "13",

pages = "8",

journal = "Polymers",

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T1 - Synthesis of functional building blocks for type III-B rotaxane dendrimer

AU - Kwan, Chak Shing

AU - Ho, Watson K.W.

AU - Chen, Yanyan

AU - Cai, Zongwei

AU - Leung, Ken Cham Fai

N1 - Funding Information: Funding: We acknowledge the financial support partially by The Hong Kong Baptist University (RC-KRPS-20-21/02). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/11/12

Y1 - 2021/11/12

N2 - Second-generation type III-B rotaxane dendrons, equipped with succinimide and acetylene functional groups, were synthesized successfully and characterized by NMR spectroscopy and mass spectrometry. A cell viability study of a dendron with a normal cell line of L929 fibroblast cells revealed no obvious cytotoxicity at a range of 5 to 100 µM. The nontoxic properties of the sophisticated rotaxane dendron building blocks provided a choice of bio-compatible macromolecular machines that could be potentially developed into polymeric materials.

AB - Second-generation type III-B rotaxane dendrons, equipped with succinimide and acetylene functional groups, were synthesized successfully and characterized by NMR spectroscopy and mass spectrometry. A cell viability study of a dendron with a normal cell line of L929 fibroblast cells revealed no obvious cytotoxicity at a range of 5 to 100 µM. The nontoxic properties of the sophisticated rotaxane dendron building blocks provided a choice of bio-compatible macromolecular machines that could be potentially developed into polymeric materials.

KW - Crown ether

KW - Fibroblast

KW - Functional dendron

KW - Macromolecular machine

KW - Rotaxane dendrimer

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U2 - 10.3390/polym13223909

DO - 10.3390/polym13223909

M3 - Journal article

AN - SCOPUS:85119380554

SN - 2073-4360

VL - 13

SP - 8

JO - Polymers

JF - Polymers

IS - 22

M1 - 3909

ER -

Synthesis of functional building blocks for type III-B rotaxane dendrimer

Abstract

Scopus Subject Areas

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