Synthesis of a kinetically stable yttrium-90 labelled macrocycle-antibody conjugate

Jonathan P.L. Cox; Karl J. Jankowski; Ritu Kataky; David Parker; Nigel R.A. Beeley; Byron A. Boyce; Michael A.W. Eaton; Kenneth Millar; Andrew T. Millican; Alice Harrison; Carole Walker

doi:10.1039/C39890000797

Synthesis of a kinetically stable yttrium-90 labelled macrocycle-antibody conjugate

Jonathan P.L. Cox
, Karl J. Jankowski
, Ritu Kataky
, David Parker
, Nigel R.A. Beeley
, Byron A. Boyce
, Michael A.W. Eaton
, Kenneth Millar
, Andrew T. Millican
, Alice Harrison
, Carole Walker

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

121 Citations (Scopus)

Abstract

Lysine is a precursor for the synthesis of an aminobutyl C-functionalised tetra-azacyclododecane tetra-acid which has been linked to B72.3 antibody and may be labelled with ⁹⁰Y to form a kinetically stable complex of potential use in radioimmunotherapy.

Original language	English
Pages (from-to)	797-798
Number of pages	2
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	12
DOIs	https://doi.org/10.1039/C39890000797
Publication status	Published - Jun 1989

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10.1039/C39890000797

Cite this

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title = "Synthesis of a kinetically stable yttrium-90 labelled macrocycle-antibody conjugate",

abstract = "Lysine is a precursor for the synthesis of an aminobutyl C-functionalised tetra-azacyclododecane tetra-acid which has been linked to B72.3 antibody and may be labelled with 90Y to form a kinetically stable complex of potential use in radioimmunotherapy.",

author = "Cox, \{Jonathan P.L.\} and Jankowski, \{Karl J.\} and Ritu Kataky and David Parker and Beeley, \{Nigel R.A.\} and Boyce, \{Byron A.\} and Eaton, \{Michael A.W.\} and Kenneth Millar and Millican, \{Andrew T.\} and Alice Harrison and Carole Walker",

year = "1989",

month = jun,

doi = "10.1039/C39890000797",

language = "English",

pages = "797--798",

journal = "Journal of the Chemical Society, Chemical Communications",

issn = "0022-4936",

publisher = "Royal Society of Chemistry",

number = "12",

}

TY - JOUR

T1 - Synthesis of a kinetically stable yttrium-90 labelled macrocycle-antibody conjugate

AU - Cox, Jonathan P.L.

AU - Jankowski, Karl J.

AU - Kataky, Ritu

AU - Parker, David

AU - Beeley, Nigel R.A.

AU - Boyce, Byron A.

AU - Eaton, Michael A.W.

AU - Millar, Kenneth

AU - Millican, Andrew T.

AU - Harrison, Alice

AU - Walker, Carole

PY - 1989/6

Y1 - 1989/6

N2 - Lysine is a precursor for the synthesis of an aminobutyl C-functionalised tetra-azacyclododecane tetra-acid which has been linked to B72.3 antibody and may be labelled with 90Y to form a kinetically stable complex of potential use in radioimmunotherapy.

AB - Lysine is a precursor for the synthesis of an aminobutyl C-functionalised tetra-azacyclododecane tetra-acid which has been linked to B72.3 antibody and may be labelled with 90Y to form a kinetically stable complex of potential use in radioimmunotherapy.

UR - https://www.scopus.com/pages/publications/0024321569

U2 - 10.1039/C39890000797

DO - 10.1039/C39890000797

M3 - Journal article

AN - SCOPUS:0024321569

SN - 0022-4936

SP - 797

EP - 798

JO - Journal of the Chemical Society, Chemical Communications

JF - Journal of the Chemical Society, Chemical Communications

IS - 12

ER -

Synthesis of a kinetically stable yttrium-90 labelled macrocycle-antibody conjugate

Abstract

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