Synthesis of β-amino acid derivatives via copper-catalyzed asymmetric 1,4-reduction of β-(acylamino)acrylates

  • Yan Wu
  • , Shan Bin Qi
  • , Fei Fei Wu
  • , Xi Chang Zhang
  • , Min Li
  • , Jing Wu*
  • , Albert S.C. Chan*
  • *Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

30 Citations (Scopus)

Abstract

A new set of reaction conditions has been established to facilitate the copper-catalyzed enantioselective 1,4-reduction of β-(acylamino)acrylates toward a selection of β-alkyl-β-amino acid derivatives in high yields and with uniformly high ee values (up to 99%) irrespective of the use of (E)- or (Z)-substrates.

Original languageEnglish
Pages (from-to)1754-1757
Number of pages4
JournalOrganic Letters
Volume13
Issue number7
Early online date2 Mar 2011
DOIs
Publication statusPublished - 1 Apr 2011

Fingerprint

Dive into the research topics of 'Synthesis of β-amino acid derivatives via copper-catalyzed asymmetric 1,4-reduction of β-(acylamino)acrylates'. Together they form a unique fingerprint.

Cite this