Synthesis, characterization, singlet-oxygen photogeneration, DNA photocleavage and two-photon-absorption properties of some (4-cyanophenyl) porphyrins

Kai Wang*, Chun Ting Poon, Rick W K WONG, Wai Yeung WONG, Chun Y. Choi, Daniel W J KWONG, Heng Zhang, Zao Ying Li

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

A series of (4-cyanophenyl)porphyrins have been prepared and structurally characterized by 1H NMR, IR and UV/Vis spectroscopy, mass spectrometry, and elemental analysis. The relative singlet-oxygen quantum yields, two-photon absorption cross-sections and DNA photocleavage activities of these porphyrins were measured. The results show that (4-cyanophenyl)porphyrins with a properly designed hydrophobic/hydrophilic balance for better cellular uptake have potential application in two-photon-absorption photodynamic therapy.

Original languageEnglish
Pages (from-to)922-928
Number of pages7
JournalEuropean Journal of Inorganic Chemistry
Issue number7
DOIs
Publication statusPublished - Mar 2009

Scopus Subject Areas

  • Inorganic Chemistry

User-Defined Keywords

  • DNA cleavage
  • Photochemistry
  • Porphyrinoids
  • Sensitizers
  • Singlet oxygen

Fingerprint

Dive into the research topics of 'Synthesis, characterization, singlet-oxygen photogeneration, DNA photocleavage and two-photon-absorption properties of some (4-cyanophenyl) porphyrins'. Together they form a unique fingerprint.

Cite this