Synthesis, characterization, singlet-oxygen photogeneration, DNA photocleavage and two-photon-absorption properties of some (4-cyanophenyl) porphyrins

Kai Wang; Chun Ting Poon; Rick W K WONG; Wai Yeung WONG; Chun Y. Choi; Daniel W J KWONG; Heng Zhang; Zao Ying Li

doi:10.1002/ejic.200801047

Synthesis, characterization, singlet-oxygen photogeneration, DNA photocleavage and two-photon-absorption properties of some (4-cyanophenyl) porphyrins

Kai Wang^*, Chun Ting Poon, Rick W K WONG, Wai Yeung WONG, Chun Y. Choi, Daniel W J KWONG, Heng Zhang, Zao Ying Li

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

29 Citations (Scopus)

Abstract

A series of (4-cyanophenyl)porphyrins have been prepared and structurally characterized by ¹H NMR, IR and UV/Vis spectroscopy, mass spectrometry, and elemental analysis. The relative singlet-oxygen quantum yields, two-photon absorption cross-sections and DNA photocleavage activities of these porphyrins were measured. The results show that (4-cyanophenyl)porphyrins with a properly designed hydrophobic/hydrophilic balance for better cellular uptake have potential application in two-photon-absorption photodynamic therapy.

Original language	English
Pages (from-to)	922-928
Number of pages	7
Journal	European Journal of Inorganic Chemistry
Issue number	7
DOIs	https://doi.org/10.1002/ejic.200801047
Publication status	Published - Mar 2009

Scopus Subject Areas

Inorganic Chemistry

User-Defined Keywords

DNA cleavage
Photochemistry
Porphyrinoids
Sensitizers
Singlet oxygen

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10.1002/ejic.200801047

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title = "Synthesis, characterization, singlet-oxygen photogeneration, DNA photocleavage and two-photon-absorption properties of some (4-cyanophenyl) porphyrins",

abstract = "A series of (4-cyanophenyl)porphyrins have been prepared and structurally characterized by 1H NMR, IR and UV/Vis spectroscopy, mass spectrometry, and elemental analysis. The relative singlet-oxygen quantum yields, two-photon absorption cross-sections and DNA photocleavage activities of these porphyrins were measured. The results show that (4-cyanophenyl)porphyrins with a properly designed hydrophobic/hydrophilic balance for better cellular uptake have potential application in two-photon-absorption photodynamic therapy.",

keywords = "DNA cleavage, Photochemistry, Porphyrinoids, Sensitizers, Singlet oxygen",

author = "Kai Wang and Poon, {Chun Ting} and WONG, {Rick W K} and WONG, {Wai Yeung} and Choi, {Chun Y.} and KWONG, {Daniel W J} and Heng Zhang and Li, {Zao Ying}",

year = "2009",

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doi = "10.1002/ejic.200801047",

language = "English",

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T1 - Synthesis, characterization, singlet-oxygen photogeneration, DNA photocleavage and two-photon-absorption properties of some (4-cyanophenyl) porphyrins

AU - Wang, Kai

AU - Poon, Chun Ting

AU - WONG, Rick W K

AU - WONG, Wai Yeung

AU - Choi, Chun Y.

AU - KWONG, Daniel W J

AU - Zhang, Heng

AU - Li, Zao Ying

PY - 2009/3

Y1 - 2009/3

N2 - A series of (4-cyanophenyl)porphyrins have been prepared and structurally characterized by 1H NMR, IR and UV/Vis spectroscopy, mass spectrometry, and elemental analysis. The relative singlet-oxygen quantum yields, two-photon absorption cross-sections and DNA photocleavage activities of these porphyrins were measured. The results show that (4-cyanophenyl)porphyrins with a properly designed hydrophobic/hydrophilic balance for better cellular uptake have potential application in two-photon-absorption photodynamic therapy.

AB - A series of (4-cyanophenyl)porphyrins have been prepared and structurally characterized by 1H NMR, IR and UV/Vis spectroscopy, mass spectrometry, and elemental analysis. The relative singlet-oxygen quantum yields, two-photon absorption cross-sections and DNA photocleavage activities of these porphyrins were measured. The results show that (4-cyanophenyl)porphyrins with a properly designed hydrophobic/hydrophilic balance for better cellular uptake have potential application in two-photon-absorption photodynamic therapy.

KW - DNA cleavage

KW - Photochemistry

KW - Porphyrinoids

KW - Sensitizers

KW - Singlet oxygen

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U2 - 10.1002/ejic.200801047

DO - 10.1002/ejic.200801047

M3 - Journal article

AN - SCOPUS:61849172877

SN - 1434-1948

SP - 922

EP - 928

JO - European Journal of Inorganic Chemistry

JF - European Journal of Inorganic Chemistry

IS - 7

ER -

Synthesis, characterization, singlet-oxygen photogeneration, DNA photocleavage and two-photon-absorption properties of some (4-cyanophenyl) porphyrins

Abstract

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