Abstract
Three heterocyclic hypervalent organoantimony chlorides RN(CH 2C6H4)2SbCl (2a R = t-Bu, 2b R = Cy, 2c R = Ph) and their chalcogenide derivatives [RN(CH2C 6H4)2Sb]2O (3a R = t-Bu, 3b R = Cy, 3c R = Ph) were synthesized and characterized by techniques such as 1H NMR, 13C NMR, X-ray diffraction, and elemental analysis. It is found that the anti-proliferative activity detected over these compounds can be attributed to the coordination bond between the antimony and nitrogen atoms of these compounds. Moreover, a preliminary study on mechanistic action suggests that the inhibition effect is ascribable to cell cycle arrest and cell apoptosis.
Original language | English |
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Pages (from-to) | 391-398 |
Number of pages | 8 |
Journal | European Journal of Medicinal Chemistry |
Volume | 79 |
DOIs | |
Publication status | Published - 22 May 2014 |
Scopus Subject Areas
- Pharmacology
- Drug Discovery
- Organic Chemistry
User-Defined Keywords
- Anti-proliferative activity
- Apoptosis
- Cell cycle arrest
- Characterization
- Hypervalent organoantimony
- Synthesis