@article{33e50091c6434f429b7ca36ede5d0b7f,
title = "Synthesis, characterization and anti-proliferative activity of heterocyclic hypervalent organoantimony compounds",
abstract = "Three heterocyclic hypervalent organoantimony chlorides RN(CH 2C6H4)2SbCl (2a R = t-Bu, 2b R = Cy, 2c R = Ph) and their chalcogenide derivatives [RN(CH2C 6H4)2Sb]2O (3a R = t-Bu, 3b R = Cy, 3c R = Ph) were synthesized and characterized by techniques such as 1H NMR, 13C NMR, X-ray diffraction, and elemental analysis. It is found that the anti-proliferative activity detected over these compounds can be attributed to the coordination bond between the antimony and nitrogen atoms of these compounds. Moreover, a preliminary study on mechanistic action suggests that the inhibition effect is ascribable to cell cycle arrest and cell apoptosis.",
keywords = "Anti-proliferative activity, Apoptosis, Cell cycle arrest, Characterization, Hypervalent organoantimony, Synthesis",
author = "Yi Chen and Kun Yu and Tan, {Nian Yuan} and Qiu, {Ren Hua} and Wei Liu and Luo, {Ning Lin} and Le Tong and Au, {Chak Tong} and Luo, {Zi Qiang} and Yin, {Shuang Feng}",
note = "Funding Information: This work was supported by the Science Research Foundation for Higher Universities of Hunan Province ( 10A092 ), Research-Based Learning and Innovation Experiment Project for Undergraduates of Hunan Province (2011-483), the National Natural Science Foundation of China ( 21003040 ), Program for Changjiang Scholars and Innovative Research Team in University ( IRT1238 ), and the Program for New Century Excellent Talents in Universities ( NCET-10-0371 ). CTA thanks HNU for an adjunct professorship. Y. Chen, K. Yun and N.Y. Tan contributed equally. Appendix A ",
year = "2014",
month = may,
day = "22",
doi = "10.1016/j.ejmech.2014.04.026",
language = "English",
volume = "79",
pages = "391--398",
journal = "European Journal of Medicinal Chemistry",
issn = "0223-5234",
publisher = "Elsevier Masson s.r.l.",
}
