Synthesis, characterization and anti-proliferative activity of heterocyclic hypervalent organoantimony compounds

Yi Chen, Kun Yu, Nian Yuan Tan, Ren Hua Qiu, Wei Liu, Ning Lin Luo, Le Tong, Chak Tong AU, Zi Qiang Luo*, Shuang Feng Yin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

Three heterocyclic hypervalent organoantimony chlorides RN(CH 2C6H4)2SbCl (2a R = t-Bu, 2b R = Cy, 2c R = Ph) and their chalcogenide derivatives [RN(CH2C 6H4)2Sb]2O (3a R = t-Bu, 3b R = Cy, 3c R = Ph) were synthesized and characterized by techniques such as 1H NMR, 13C NMR, X-ray diffraction, and elemental analysis. It is found that the anti-proliferative activity detected over these compounds can be attributed to the coordination bond between the antimony and nitrogen atoms of these compounds. Moreover, a preliminary study on mechanistic action suggests that the inhibition effect is ascribable to cell cycle arrest and cell apoptosis.

Original languageEnglish
Pages (from-to)391-398
Number of pages8
JournalEuropean Journal of Medicinal Chemistry
Volume79
DOIs
Publication statusPublished - 22 May 2014

Scopus Subject Areas

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

User-Defined Keywords

  • Anti-proliferative activity
  • Apoptosis
  • Cell cycle arrest
  • Characterization
  • Hypervalent organoantimony
  • Synthesis

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