Synthesis and photodynamic activities of modified corrole derivatives on nasopharyngeal carcinoma cells

Chi K. Chang*, Pak Wing Kong, Hai Yang Liu, Lam Lung Yeung, Ho Kee Koon, Nai Ki MAK

*Corresponding author for this work

Research output: Chapter in book/report/conference proceedingConference contributionpeer-review

23 Citations (Scopus)

Abstract

Ten trans-A2B and A3-type corroie photosensitizers carrying functional groups were synthesized and screened for PDT activities. Photocytotoxicity was measured by the MTT cell reduction assay on a cultured human nasopharyngeal carcinoma (NPC) cell line (HONE-1). Experimental results indicated that corroies containing a single hydroxyphenyl substituent (3, 4 and 5) exhibit the highest activity among the corroie derivatives investigated. Confocal microscopy revealed that the site of cellular localization of the photosensitizers is predominantly at mitochondria. Also, nuclear staining detected apoptotic cell death.

Original languageEnglish
Title of host publicationOptical Methods for Tumor Treatment and Detection
Subtitle of host publicationMechanisms and Techniques in Photodynamic Therapy XV
DOIs
Publication statusPublished - 2006
EventOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV - San Jose, CA, United States
Duration: 21 Jan 200622 Jan 2006

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6139
ISSN (Print)1605-7422

Conference

ConferenceOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV
Country/TerritoryUnited States
CitySan Jose, CA
Period21/01/0622/01/06

Scopus Subject Areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

User-Defined Keywords

  • Corroie
  • Nasopharyngeal carcinoma
  • Photosensitizer
  • Porphyrin

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