Synthesis and photodynamic activities of modified corrole derivatives on nasopharyngeal carcinoma cells

Chi K. Chang; Pak Wing Kong; Hai Yang Liu; Lam Lung Yeung; Ho Kee Koon; Nai Ki Mak

doi:10.1117/12.646328

Synthesis and photodynamic activities of modified corrole derivatives on nasopharyngeal carcinoma cells

Chi K. Chang^*, Pak Wing Kong, Hai Yang Liu, Lam Lung Yeung, Ho Kee Koon, Nai Ki Mak

^*Corresponding author for this work

Department of Biology

Research output: Chapter in book/report/conference proceeding › Conference proceeding › peer-review

30 Citations (Scopus)

Abstract

Ten trans-A₂B and A₃-type corroie photosensitizers carrying functional groups were synthesized and screened for PDT activities. Photocytotoxicity was measured by the MTT cell reduction assay on a cultured human nasopharyngeal carcinoma (NPC) cell line (HONE-1). Experimental results indicated that corroies containing a single hydroxyphenyl substituent (3, 4 and 5) exhibit the highest activity among the corroie derivatives investigated. Confocal microscopy revealed that the site of cellular localization of the photosensitizers is predominantly at mitochondria. Also, nuclear staining detected apoptotic cell death.

Original language	English
Title of host publication	Optical Methods for Tumor Treatment and Detection
Subtitle of host publication	Mechanisms and Techniques in Photodynamic Therapy XV
DOIs	https://doi.org/10.1117/12.646328
Publication status	Published - 2006
Event	Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV - San Jose, CA, United States Duration: 21 Jan 2006 → 22 Jan 2006

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	6139
ISSN (Print)	1605-7422

Conference

Conference	Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV
Country/Territory	United States
City	San Jose, CA
Period	21/01/06 → 22/01/06

Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging

User-Defined Keywords

Corroie
Nasopharyngeal carcinoma
Photosensitizer
Porphyrin

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10.1117/12.646328

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Chang, C. K., Kong, P. W., Liu, H. Y., Yeung, L. L., Koon, H. K., & Mak, N. K. (2006). Synthesis and photodynamic activities of modified corrole derivatives on nasopharyngeal carcinoma cells. In Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV Article 613915 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6139). https://doi.org/10.1117/12.646328

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title = "Synthesis and photodynamic activities of modified corrole derivatives on nasopharyngeal carcinoma cells",

abstract = "Ten trans-A2B and A3-type corroie photosensitizers carrying functional groups were synthesized and screened for PDT activities. Photocytotoxicity was measured by the MTT cell reduction assay on a cultured human nasopharyngeal carcinoma (NPC) cell line (HONE-1). Experimental results indicated that corroies containing a single hydroxyphenyl substituent (3, 4 and 5) exhibit the highest activity among the corroie derivatives investigated. Confocal microscopy revealed that the site of cellular localization of the photosensitizers is predominantly at mitochondria. Also, nuclear staining detected apoptotic cell death.",

keywords = "Corroie, Nasopharyngeal carcinoma, Photosensitizer, Porphyrin",

author = "Chang, {Chi K.} and Kong, {Pak Wing} and Liu, {Hai Yang} and Yeung, {Lam Lung} and Koon, {Ho Kee} and Mak, {Nai Ki}",

note = "Copyright: Copyright 2008 Elsevier B.V., All rights reserved.; Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV ; Conference date: 21-01-2006 Through 22-01-2006",

year = "2006",

doi = "10.1117/12.646328",

language = "English",

isbn = "0819461822",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

booktitle = "Optical Methods for Tumor Treatment and Detection",

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Chang, CK, Kong, PW, Liu, HY, Yeung, LL, Koon, HK & Mak, NK 2006, Synthesis and photodynamic activities of modified corrole derivatives on nasopharyngeal carcinoma cells. in Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV., 613915, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 6139, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV, San Jose, CA, United States, 21/01/06. https://doi.org/10.1117/12.646328

Synthesis and photodynamic activities of modified corrole derivatives on nasopharyngeal carcinoma cells. / Chang, Chi K.; Kong, Pak Wing; Liu, Hai Yang et al.
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV. 2006. 613915 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6139).

Research output: Chapter in book/report/conference proceeding › Conference proceeding › peer-review

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T1 - Synthesis and photodynamic activities of modified corrole derivatives on nasopharyngeal carcinoma cells

AU - Chang, Chi K.

AU - Kong, Pak Wing

AU - Liu, Hai Yang

AU - Yeung, Lam Lung

AU - Koon, Ho Kee

AU - Mak, Nai Ki

PY - 2006

Y1 - 2006

N2 - Ten trans-A2B and A3-type corroie photosensitizers carrying functional groups were synthesized and screened for PDT activities. Photocytotoxicity was measured by the MTT cell reduction assay on a cultured human nasopharyngeal carcinoma (NPC) cell line (HONE-1). Experimental results indicated that corroies containing a single hydroxyphenyl substituent (3, 4 and 5) exhibit the highest activity among the corroie derivatives investigated. Confocal microscopy revealed that the site of cellular localization of the photosensitizers is predominantly at mitochondria. Also, nuclear staining detected apoptotic cell death.

AB - Ten trans-A2B and A3-type corroie photosensitizers carrying functional groups were synthesized and screened for PDT activities. Photocytotoxicity was measured by the MTT cell reduction assay on a cultured human nasopharyngeal carcinoma (NPC) cell line (HONE-1). Experimental results indicated that corroies containing a single hydroxyphenyl substituent (3, 4 and 5) exhibit the highest activity among the corroie derivatives investigated. Confocal microscopy revealed that the site of cellular localization of the photosensitizers is predominantly at mitochondria. Also, nuclear staining detected apoptotic cell death.

KW - Corroie

KW - Nasopharyngeal carcinoma

KW - Photosensitizer

KW - Porphyrin

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DO - 10.1117/12.646328

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SN - 0819461822

SN - 9780819461827

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Optical Methods for Tumor Treatment and Detection

T2 - Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV

Y2 - 21 January 2006 through 22 January 2006

ER -

Chang CK, Kong PW, Liu HY, Yeung LL, Koon HK, Mak NK. Synthesis and photodynamic activities of modified corrole derivatives on nasopharyngeal carcinoma cells. In Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV. 2006. 613915. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.646328

Synthesis and photodynamic activities of modified corrole derivatives on nasopharyngeal carcinoma cells

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