Synthesis and photodynamic activities of modified benzochlorin derivatives on nasopharyngeal carcinoma cells

Chi K. Chang*, Yan Kin Lau, Tat Shing Lai, Lam Lung Yeung, Wing Nang Leung, Nai Ki MAK

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review


Nasopharyngeal carcinoma (NPC), endemic in Southern China, is ranked as the fourth leading cause of cancer deaths in Hong Kong. In an effort to develop new PDT agents for cancer treatment, with a particular emphasis on the NPC, we have investigated the benzochlorin-type photosensitizers. The chromophore is functionalized with side chains containing polar and/or cationic groups. Synthetic methods have been developed for such purposes; e.g. 5 2-chlorosulfonyloctaethylbenzochlorin and 5 2-bromooctaethylbenzochlorin are used as versatile precursors for the preparation of ammonium and amidinium salts. Preliminary in vitro study of the photodynamic activity of the synthetic compounds indicated that the cationic benzochlorin derivatives display significant photocytotoxicity towards NPC cells.

Original languageEnglish
Pages (from-to)49-60
Number of pages12
JournalProceedings of SPIE - The International Society for Optical Engineering
Publication statusPublished - 2004
EventProgress in Biomedical Optics and Imaging - Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamics Therapy XIII - San Jose, CA, United States
Duration: 24 Jan 200425 Jan 2004

Scopus Subject Areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

User-Defined Keywords

  • Bromobenzochlorin
  • Pd-catalyzed coupling
  • Photosensitizer


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