Synthesis and DNA-binding affinities of protoberberine-based multivalent agents

Jie Shun Cui, Fang Xu, Ji Yan Pang*, Wen Hua Chen*, Zhi Hong Jiang

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

10 Citations (Scopus)
15 Downloads (Pure)


Three novel berberine derivatives bearing two, three, and four primary amino groups at C(9), respectively, were synthesized and characterized on the basis of 1H- and 13C-NMR, MS, and HR-MS data. Their non-covalent binding with calf thymus (CT) DNA was investigated by means of spectrophotometric titration and ethidium bromide (EB) displacement experiments. The results indicated that these multivalent berberine derivatives exhibited up to 130-fold enhanced binding affinities relative to berberine, and thus, may be exploitable as potent DNA-binding agents.

Original languageEnglish
Pages (from-to)2908-2916
Number of pages9
JournalChemistry and Biodiversity
Issue number12
Publication statusPublished - Dec 2010

Scopus Subject Areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Molecular Medicine
  • Molecular Biology

User-Defined Keywords

  • Berberine derivatives
  • DNA
  • Polyamines
  • Protoberberine


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