Synthesis and DNA-binding affinities of monomodified berberines

Ji Yan Pang, Yong Qin, Wen Hua Chen*, Guo An Luo, Zhi Hong JIANG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

60 Citations (Scopus)

Abstract

Four new monomodified berberines have been synthesized in moderate to good yields starting from berberine and fully characterized by HRMS and 1H NMR. Spectrometric titration and ethidium bromide displacement experiments indicate that these berberine derivatives, especially the one having primary amino group, strongly bind with calf-thymus DNA, presumably via an intercalation mechanism.

Original languageEnglish
Pages (from-to)5835-5840
Number of pages6
JournalBioorganic and Medicinal Chemistry
Volume13
Issue number20
DOIs
Publication statusPublished - 15 Oct 2005

Scopus Subject Areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

User-Defined Keywords

  • Berberine
  • DNA-binder
  • Spectrometry
  • Synthesis

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