TY - JOUR
T1 - Synthesis and characterization of some metal complexes of 4,5-diazafluoren-9-one and their biological effects on human carcinoma cells
AU - Lu, Guo Liang
AU - HO, Cheuk Lam
AU - Wang, Qiwei
AU - WONG, Wai Yeung
AU - CHUI, Chung Hin
AU - Wong, Raymond Siu Ming
AU - Gambari, Roberto
AU - Lau, Fung Yi
AU - Yuen, Marcus Chun Wah
AU - Tong, Cindy Sze Wai
AU - Chan, Andrew Kit Wah
AU - Tang, Johnny Cheuk On
AU - Ho, Kwok Ping
AU - Cheng, Gregory Yin Ming
N1 - Funding Information:
Financial support from a Competitive Earmarked Research Grant (CERG) Grant from the Hong Kong Research Grants Council of the Hong Kong SAR, China (Project no. HKBU2021/06P) and Hong Kong Baptist University is gratefully acknowledged (to W.-Y. Wong). We also acknowledge financial support from the Haematology Research Funding, Haematology Division, Department of Medicine and Therapeutics, Prince of Wales Hospital, the Chinese University of Hong Kong, and the internal research grants offered by the Hong Kong Polytechnic University to Dr K.-P. Ho (Grant no. PA3F and 879D). R. Gambari is supported by a grant from Italian Association for Cancer Research (AIRC).
PY - 2008/12
Y1 - 2008/12
N2 - Three new transition metal complexes of 4,5-diazafluoren-9-one, [(DAFO)PdCl2], [(DAFO)PtCl2], and [(DAFO)ZnCl 2], were prepared in good yields by the reactions between appropriate metal chloride precursors and 4,5-diazafluoren-9-one under ambient conditions. The structures of these metal complexes were established by spectroscopic (Fourier-transform IR, NMR, and fast-atom bombardment mass spectrometry) techniques. The possible biological activity of these compounds on three human cancer cell lines including Hep3B, MDAMB-231, and SKHep-1 was investigated. The results obtained showed that both zinc- and platinum-containing compounds exhibit a similar growth inhibitory effect on these three cancer cell lines when compared with the prototypical cis-platin. In contrast, the corresponding palladium congener is virtually biologically inactive in these trials.
AB - Three new transition metal complexes of 4,5-diazafluoren-9-one, [(DAFO)PdCl2], [(DAFO)PtCl2], and [(DAFO)ZnCl 2], were prepared in good yields by the reactions between appropriate metal chloride precursors and 4,5-diazafluoren-9-one under ambient conditions. The structures of these metal complexes were established by spectroscopic (Fourier-transform IR, NMR, and fast-atom bombardment mass spectrometry) techniques. The possible biological activity of these compounds on three human cancer cell lines including Hep3B, MDAMB-231, and SKHep-1 was investigated. The results obtained showed that both zinc- and platinum-containing compounds exhibit a similar growth inhibitory effect on these three cancer cell lines when compared with the prototypical cis-platin. In contrast, the corresponding palladium congener is virtually biologically inactive in these trials.
UR - https://www.scopus.com/pages/publications/57649228057
U2 - 10.1071/CH08342
DO - 10.1071/CH08342
M3 - Journal article
AN - SCOPUS:57649228057
SN - 0004-9425
VL - 61
SP - 975
EP - 980
JO - Australian Journal of Chemistry
JF - Australian Journal of Chemistry
IS - 12
ER -
SDG 3 Good Health and Well-being